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  4. Recombinant Arabidopsis thaliana Serine/threonine-protein kinase ATR (ATR), partial

Recombinant Arabidopsis thaliana Serine/threonine-protein kinase ATR (ATR), partial

  • 中文名称：
    Recombinant Arabidopsis thaliana Serine/threonine-protein kinase ATR(ATR) ,partial
  • 货号：
    CSB-YP863791DOA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Arabidopsis thaliana Serine/threonine-protein kinase ATR(ATR) ,partial
  • 货号：
    CSB-EP863791DOA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Arabidopsis thaliana Serine/threonine-protein kinase ATR(ATR) ,partial
  • 货号：
    CSB-EP863791DOA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Arabidopsis thaliana Serine/threonine-protein kinase ATR(ATR) ,partial
  • 货号：
    CSB-BP863791DOA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Arabidopsis thaliana Serine/threonine-protein kinase ATR(ATR) ,partial
  • 货号：
    CSB-MP863791DOA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    ATR
  • Uniprot No.：
    Q9FKS4
  • 别名：
    ATR; RAD3; At5g40820; MHK7.5Serine/threonine-protein kinase ATR; AtATR; EC 2.7.11.1; Ataxia telangiectasia-mutated and Rad3-related homolog; DNA repair protein ATR; Rad3-like protein; AtRAD3
  • 种属：
    Arabidopsis thaliana (Mouse-ear cress)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Probable serine/threonine kinase. Plays a central role in cell-cycle regulation by transmitting DNA damage signals to downstream effectors of cell-cycle progression. May recognize the substrate consensus sequence [ST]-Q and phosphorylate histone variant H2AX to form H2AXS139ph at sites of DNA damage, thereby regulating DNA damage response mechanism. Seems to be required for the G2-phase checkpoint in response to replication blocks but not absolutely required in the G2-arrest response to double-strand breaks. May also be involved in the meiosis process. Required for the basal expression of RNR1 (ribonucleotide reductase large subunit). Acts in concert with telomerase to maintain telomeric DNA tracts. Not required for telomere length homeostasis. Required for effective immune responses that involve activation of DNA damage responses.
  • 基因功能参考文献：
    1. ATR function together with SOG1 and ALT2 to halt root growth and promote terminal differentiation in response to chronic Aluminum exposure. PMID: 26320227
    2. Data suggest that an RNA G-quadruplex of the G(3)L(1-7) class resides in the 5prime-untranslated region of ATR mRNA and appears to function in down-regulation of mRNA translation. PMID: 25793418
    3. Data show that the ATM-SOG1 and ATR-SOG1 pathways both transmit DSB-derived signals and that either one suffices for endocycle induction. PMID: 21613568
    4. The MRN complex is essential for activation of the ATM and ATR kinases in response to irradiation. PMID: 20876831
    5. Both ATM and ATR contribute to the induction of a CYCB1;1:GUS fusion by IR, but only ATR is required for the persistence of this response. [ATR] PMID: 17227549
    6. Aluminum-dependent root-growth inhibition primarily arises from DNA damage coupled with AtATR-controlled blockage of cell-cycle progression and terminal differentiation because of loss of the root-quiescent center. PMID: 18835170

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    PI3/PI4-kinase family, ATM subfamily
  • 数据库链接：

    KEGG: ath:AT5G40820

    STRING: 3702.AT5G40820.1

    UniGene: At.475

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