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  4. Recombinant Arabidopsis thaliana Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH4 (SUVH4), partial

Recombinant Arabidopsis thaliana Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH4 (SUVH4), partial

  • 中文名称：
    拟南芥SUVH4重组蛋白
  • 货号：
    CSB-YP810174DOA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    拟南芥SUVH4重组蛋白
  • 货号：
    CSB-EP810174DOA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    拟南芥SUVH4重组蛋白
  • 货号：
    CSB-EP810174DOA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    拟南芥SUVH4重组蛋白
  • 货号：
    CSB-BP810174DOA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    拟南芥SUVH4重组蛋白
  • 货号：
    CSB-MP810174DOA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    SUVH4
  • Uniprot No.：
    Q8GZB6
  • 别名：
    SUVH4; KYP; SDG33; SET33; At5g13960; MAC12.7; Histone-lysine N-methyltransferase; H3 lysine-9 specific SUVH4; EC 2.1.1.-; Histone H3-K9 methyltransferase 4; H3-K9-HMTase 4; Protein KRYPTONITE; Protein SET DOMAIN GROUP 33; Suppressor of variegation 3-9 homolog protein 4; Su(var)3-9 homolog protein 4
  • 种属：
    Arabidopsis thaliana (Mouse-ear cress)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Histone methyltransferase. Methylates 'Lys-9' of histone H3. H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional repression. The silencing mechanism via DNA CpNpG methylation requires the targeting of chromomethylase CMT3 to methylated histones, probably through an interaction with an HP1-like adapter. By its function, KYP is directly required for the maintenance of the DNA CpNpG and asymmetric methylation. Involved in the silencing of transposable elements.
  • 基因功能参考文献：
    1. CMT3-SUVH4 is the major pathway controlling silencing of the exonic Evelknievel retroelement via inducing non-CG methylation. PMID: 30446008
    2. The authors conclude that geminivirus TrAP attenuates the transcriptional gene silencing of the viral chromatin by inhibiting KYP activity to evade host surveillance. PMID: 26344546
    3. The structures of KYP and previously reported CMT3 complexes provide insights into molecular mechanisms linking DNA and histone methylation. PMID: 25018018
    4. Genetic analysis showed that DOG1 and HUB1 are epistatic to KYP/SUVH4, suggesting that these genes regulate seed dormancy in the same genetic pathway. PMID: 22122546
    5. H3 lysine 9 methylation epigenetic modifications are reduced in an suvh4 suvh6 double mutant PMID: 16287862

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  • 亚细胞定位：
    Nucleus. Chromosome. Chromosome, centromere. Note=Associates with centromeric constitutive heterochromatin and at a lower level with regions of euchromatin.
  • 蛋白家族：
    Class V-like SAM-binding methyltransferase superfamily, Histone-lysine methyltransferase family, Suvar3-9 subfamily
  • 组织特异性：
    Expressed in leaves stems and flowers.
  • 数据库链接：

    KEGG: ath:AT5G13960

    STRING: 3702.AT5G13960.1

    UniGene: At.8330

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