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  4. Recombinant MouseV-set domain containing T-cell activation inhibitor 1 (Vtcn1)

Recombinant MouseV-set domain containing T-cell activation inhibitor 1 (Vtcn1)

  • 中文名称：
    Recombinant MouseV-set domain containing T-cell activation inhibitor 1 (Vtcn1)
  • 货号：
    CSB-MP742524MO
  • 规格：
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 95% as determined by SDS-PAGE.
  • 生物活性：
    Not Test
  • 基因名：
    Vtcn1
  • Uniprot No.：
    Q7TSP5
  • 别名：
    B7 homolog 4;B7-H4;Immune costimulatory protein B7-H4;Protein B7S1;T cell costimulatory molecule B7x
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 来源：
    Mammalian cell
  • 分子量：
    27.0 kDa
  • 表达区域：
    25-257aa
  • 氨基酸序列
    LIIGFGISGKHFITVTTFTSAGNIGEDGTLSCTFEPDIKLNGIVIQWLKEGIKGLVHEFKEGKDDLSQQHEMFRGRTAVFADQVVVGNASLRLKNVQLTDAGTYTCYIRTSKGKGNANLEYKTGAFSMPEINVDYNASSESLRCEAPRWFPQPTVAWASQVDQGANFSEVSNTSFELNSENVTMKVVSVLYNVTINNTYSCMIENDIAKATGDIKVTDSEVKRRSQLQLLNSG
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    C-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 3-7 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

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Vtcn1 Proteins

靶点详情

  • 功能：
    Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation.
  • 基因功能参考文献：
    1. this study shows that B7-H4 knockout hosts mount greater tumor-associated anti-tumor T cell responses and display reduced tumors PMID: 28074226
    2. Results highlight an importance of VTCN1 stabilization on cell surfaces for the restoration of altered balance of immune control during T1D. PMID: 26773144
    3. B7-H4 expression by nonhematopoietic cells in the tumor microenvironment promotes antitumor immunity. PMID: 25527357
    4. that B7x can modulate kidney damage in autoimmune diseases including lupus nephritis and anti-glomerular basement membrane disease PMID: 25205493
    5. B7-H4 can inhibit both antitumor T cells and protumor myeloid-derived suppressor cells ( PMID: 23686485
    6. The endogenous expression of B7-H4 in donor beta cells from transgenic mice prolongs islet allograft survival, confirming the negative role of B7-H4 in regulating alloreactive T-cell responses. PMID: 23192157
    7. Local overexpression of B7x on pancreatic beta cells is sufficient to abolish CD8 T cell-induced diabetes. PMID: 22972920
    8. An enhanced T cell response contributes to reduced lethality in a pulmonary infection model with Streptococcus pneumoniae. PMID: 22855708
    9. B7-H4 expression may influence the outcome of T-cell tumor cell interactions. Tumor-associated macrophage induced membrane-bound B7-H4 on lung cancer cell represents a novel mechanism by which lung cancer cells evade immune recognition and destruction. PMID: 22108530
    10. Overexpression of B7-H4 was shown in tumor infiltrated dendritic cells. PMID: 21728826
    11. Tissue-specific expression of B7x protects from CD4 T cell-mediated autoimmunity. PMID: 21727190
    12. intact recipient, but not donor, B7-H4 is essential for prolongation of allograft survival by blocking CD28/CTLA4:B7 pathway using CTLA4-Ig. PMID: 21143433
    13. studies reveal a novel role for activated hepatic stellate cells in the attenuation of intrahepatic T cell responses by way of expression of the coinhibitory molecule B7-H4. PMID: 21064155
    14. May participate in negative regulation of cell-mediated immunity in peripheral tissues PMID: 12818165
    15. novel negative costimulator and regulates the threshold of T cell activation PMID: 12818166
    16. Genomic DNA of mouse B7-H4 is mapped on chromosome 3 comprised of six exons and five introns spanning 66 kb. PMID: 14568939
    17. These results suggest that B7-H4 is one of multiple negative cosignaling molecules that collectively provide a fine-tuning mechanism for T-cell-mediated immune responses. PMID: 16914726
    18. T-cell and epithelial cell crosstalk-associated B7-H4 induces T-cell activation and is a potential activator that promotes tubular lesion PMID: 17051145
    19. B7-H4 is a negative regulator of the neutrophil response to infection PMID: 19109567
    20. Local expression of B7-H4 prolongs islet allograft survival in vivo, suggesting translational potential for beta-cell replacement with reduced immune injury. PMID: 19307783
    21. these results suggest a different action of B7-H4 in T cell-mediated inflammatory responses and the possible involvement of soluble B7-H4 in inflammatory immune responses. PMID: 19723502

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  • 亚细胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor.
  • 蛋白家族：
    Immunoglobulin superfamily, BTN/MOG family
  • 组织特异性：
    Expressed on the surface of professional antigen-presenting cells (at protein level). Widely expressed, including in kidney, liver, lung, pancreas, placenta, prostate, spleen, testis and thymus.
  • 数据库链接：

    KEGG: mmu:242122

    STRING: 10090.ENSMUSP00000057721

    UniGene: Mm.137467

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