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  4. UAP1 Recombinant Monoclonal Antibody

UAP1 Recombinant Monoclonal Antibody

说明书
  • 中文名称：
    UAP1重组抗体
  • 货号：
    CSB-RA174034A0HU
  • 规格：
    ￥1320
  • 图片：
    • Western Blot
      Positive WB detected in: K562 whole cell lysate
      All lanes: UAP1 antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 59, 58, 59 kDa
      Observed band size: 59 kDa
  • 其他：

产品详情

  • 产品描述：
    CSB-RA174034A0HU UAP1重组单克隆抗体是经严格验证的高特异性科研工具，适用于ELISA和Western Blot实验，其中WB推荐使用1:500-1:5000的稀释范围。该抗体靶向UAP1蛋白，该蛋白作为尿苷二磷酸-N-乙酰葡糖胺焦磷酸化酶，负责催化糖核苷酸合成，在蛋白质糖基化修饰和细胞外基质形成中起关键作用，其异常表达与肿瘤发生及糖代谢紊乱密切相关。经实验验证，该抗体在多种细胞裂解液中均能有效识别目标蛋白，呈现单一清晰条带，且在低浓度样本中仍保持高灵敏度，背景信号显著低于同类产品。ELISA应用中表现出优异的线性检测范围和批次间稳定性，满足定量分析的实验需求。本产品适用于探究UAP1在糖基化通路调控、肿瘤细胞异常增殖机制以及代谢性疾病模型中的分子作用，可配合细胞转染、蛋白互作等实验方案，为糖生物学研究和疾病相关分子机制探索提供可靠检测工具。
  • Uniprot No.：
    Q16222
  • 基因名：
    UAP1
  • 别名：
    UDP-N-acetylhexosamine pyrophosphorylase (Antigen X) (AGX) (Sperm-associated antigen 2) [Includes: UDP-N-acetylgalactosamine pyrophosphorylase (EC 2.7.7.83) (AGX-1), UDP-N-acetylglucosamine pyrophosphorylase (EC 2.7.7.23) (AGX-2)], UAP1, SPAG2
  • 反应种属：
    Human
  • 免疫原：
    A synthesized peptide derived from human UAP1
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Monoclonal
  • 抗体亚型：
    Rabbit IgG
  • 纯化方式：
    Affinity-chromatography
  • 克隆号：
    1F2
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
  • Protocols：
    ELISA Protocol
    Western Blotting (WB) Protocol
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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UAP1 antibodies

UAP1 Proteins

靶点详情

  • 功能：
    Converts UTP and GlcNAc-1-P into UDP-GlcNAc, and UTP and GalNAc-1-P into UDP-GalNAc. Isoform AGX1 has 2 to 3 times higher activity towards GalNAc-1-P, while isoform AGX2 has 8 times more activity towards GlcNAc-1-P.
  • 基因功能参考文献：
    1. Results identified an enzyme, UAP1, which is highly overexpressed in prostate cancer and protects cancer cells from endoplasmic reticulum stress conferring a growth advantage. PMID: 25241896
  • 亚细胞定位：
    Cytoplasm. Note=In spermatozoa, localized to the principal piece of the tail, the neck region of the head and to a lesser extent, the midpiece of the tail.
  • 蛋白家族：
    UDPGP type 1 family
  • 组织特异性：
    Widely expressed. Isoform AGX1 is more abundant in testis than isoform AGX2, while isoform AGX2 is more abundant than isoform AGX1 in somatic tissue. Expressed at low level in placenta, muscle and liver.
  • 数据库链接：

    HGNC: 12457

    OMIM: 602862

    KEGG: hsa:6675

    STRING: 9606.ENSP00000356903

    UniGene: Hs.492859

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