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TBR1 Recombinant Monoclonal Antibody

  • 中文名称:
    TBR1重组抗体
  • 货号:
    CSB-RA618090A0HU
  • 规格:
    ¥1320
  • 其他:

产品详情

  • 产品描述:
    CSB-RA618090A0HU TBR1重组单克隆抗体是通过重组蛋白免疫技术制备的高特异性抗体,靶向T-box脑转录因子1(TBR1)。该蛋白作为关键转录调控因子,参与大脑皮层神经元的分化、突触形成及神经回路建立等过程,其功能异常与神经发育障碍相关。本产品经ELISA方法严格验证,具备高亲和力与特异性,能稳定识别天然构象的TBR1蛋白,不同批次间性能高度一致。适用于神经发育机制研究、皮层神经元分化模型验证、自闭症或癫痫等疾病相关信号通路分析等基础科研领域。抗体采用无动物成分表达系统生产,避免交叉反应风险,可为神经生物学研究提供可靠的实验工具,尤其适用于体外蛋白互作分析及功能研究中的靶标定量检测需求。
  • Uniprot No.:
  • 基因名:
    TBR1
  • 别名:
    T box brain 1 antibody; T box brain protein 1 antibody; T brain 1 protein antibody; T-box brain protein 1 antibody; T-brain-1 antibody; TBR 1 antibody; TBR-1 antibody; Tbr1 antibody; TBR1_HUMAN antibody; TES 56 antibody; TES-56 antibody
  • 反应种属:
    Human
  • 免疫原:
    A synthesized peptide derived from human TBR1
  • 免疫原种属:
    Homo sapiens (Human)
  • 标记方式:
    Non-conjugated
  • 克隆类型:
    Monoclonal
  • 抗体亚型:
    Rabbit IgG
  • 纯化方式:
    Affinity-chromatography
  • 克隆号:
    2E10
  • 浓度:
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液:
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • 产品提供形式:
    Liquid
  • 应用范围:
    ELISA
  • Protocols:
  • 储存条件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

产品评价

靶点详情

  • 功能:
    Transcriptional repressor involved in multiple aspects of cortical development, including neuronal migration, laminar and areal identity, and axonal projection. As transcriptional repressor of FEZF2, it blocks the formation of the corticospinal (CS) tract from layer 6 projection neurons, thereby restricting the origin of CS axons specifically to layer 5 neurons.
  • 基因功能参考文献:
    1. TBR1 homodimerizes; it interacts with FOXP2, a transcription factor implicated in speech/language disorders, and this interaction is disrupted by pathogenic mutations affecting either protein PMID: 25232744
  • 亚细胞定位:
    Nucleus.
  • 组织特异性:
    Brain.
  • 数据库链接:

    HGNC: 11590

    OMIM: 604616

    KEGG: hsa:10716

    STRING: 9606.ENSP00000374205

    UniGene: Hs.210862