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  4. NUDC Recombinant Monoclonal Antibody

NUDC Recombinant Monoclonal Antibody

说明书
  • 中文名称：
    NUDC重组抗体
  • 货号：
    CSB-RA906015A0HU
  • 规格：
    ￥1320
  • 图片：
    • Western Blot
      Positive WB detected in: Hela whole cell lysate, 293 whole cell lysate, K562 whole cell lysate, 293T whole cell lysate, A549 whole cell lysate, Rat Brain whole cell lysate, Mouse Brain whole cell lysate
      All lanes: NUDC antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 39 kDa
      Observed band size: 45 kDa
  • 其他：

产品详情

  • 产品描述：
    CSB-RA906015A0HU NUDC重组单克隆抗体是针对核分布蛋白C（NUDC）研发的高特异性科研试剂，适用于ELISA和Western Blot（WB）实验，其中WB推荐使用稀释比例为1:500至1:5000。该抗体靶向的NUDC蛋白在细胞核迁移、纺锤体组装及有丝分裂过程中发挥关键作用，其表达异常与细胞周期失调及肿瘤发生密切相关。经多物种细胞裂解液及组织样本验证，本产品可特异性识别天然构象下的NUDC蛋白，检测结果呈现单一清晰条带，重复性优异。严格的质量控制体系确保了批次间的高一致性，适用于低丰度样本检测。科研人员可将其应用于细胞分裂机制研究、肿瘤微环境分析或药物靶点筛选等基础研究领域，尤其为探究NUDC在癌症进展、神经发育障碍中的分子机制提供可靠工具。该抗体适用于常规实验室条件下使用，满足分子生物学及细胞生物学实验对精准检测的需求。
  • Uniprot No.：
    Q9Y266
  • 基因名：
    NUDC
  • 别名：
    Nuclear migration protein nudC (Nuclear distribution protein C homolog), NUDC
  • 反应种属：
    Human, Mouse, Rat
  • 免疫原：
    A synthesized peptide derived from human NUDC
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Monoclonal
  • 抗体亚型：
    Rabbit IgG
  • 纯化方式：
    Affinity-chromatography
  • 克隆号：
    6C3
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
  • Protocols：
    ELISA Protocol
    Western Blotting (WB) Protocol
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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NUDC antibodies

靶点详情

  • 功能：
    Plays a role in neurogenesis and neuronal migration. Necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Necessary for cytokinesis and cell proliferation.
  • 基因功能参考文献：
    1. High expression of NUDC is associated with prostate cancer. PMID: 27959429
    2. the upregulation of miR-194 affects the hNUDC expression, leading to a downregulated expression of Mpl/ERK pathway proteins, and suppresses the mitosis and proliferation of NSCLC cells. PMID: 27035759
    3. NudC is co-localized with Aurora B at the midbody and co-immunoprecipitated with Aurora B in mitosis. results suggest that that dynamic phosphorylation of NudC by Aurora B regulates cytokinesis. PMID: 27074040
    4. NudC acetylation/deacetylation regulates mitotic progression and NudC deacetylation, likely through HDAC3, is critical for spindle function and chromosome congression. PMID: 24069238
    5. Human nuclear distribution C is found to be closely associated with cell malignant hyperplasia in nasopharyngeal carcinoma. PMID: 21473139
    6. NudC may be involved in the regulation of LIS1 stability by its chaperone function. PMID: 20675372
    7. separate binding sites on the Mpl receptor for TPO and hNUDC identified PMID: 20529857
    8. Mpl plays an important and specific role in mediating hNUDC-induced megakaryocyte proliferation and differentiation. PMID: 19560457
    9. functions in mitosis and cytokinesis, in part by regulating microtubule organization at the midzone and midbody PMID: 12679384
    10. PLK1 phosphorylation of NudC plays an essential role in cytokinesis. PMID: 12852857
    11. Overexpression of NUDC inhibits prostatic neoplasm growth. PMID: 14676831
    12. In this study, we report the binding of hNUDC to the extracellular domain of the thrombopoietin receptor (Mpl) as detected by the yeast two-hybrid system, GST pull-down, and co-immunoprecipitation. PMID: 16088917
    13. NudC functions as both a substrate and a spatial regulator of Plk1 at the kinetochore to promote chromosome congression. PMID: 16860740
    14. hNUDC induced significant changes in cellular morphology in NIH 3T3 cells stably transfected with pMpl-EGFP. Interestingly, these morphological changes were characteristic of cells undergoing megakaryocyte differentiation. PMID: 17658515
    15. hNUDC induced a sustained activation of the extracellular signal-regulated protein kinases-1 and -2 (ERK1/2) as well as p38 mitogen-activated kinase (p38 MAPK) pathways PMID: 18288130

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  • 亚细胞定位：
    Cytoplasm, cytoskeleton. Nucleus. Cytoplasm, cytoskeleton, spindle. Midbody.
  • 蛋白家族：
    NudC family
  • 组织特异性：
    Ubiquitous. Highly expressed in fetal liver, kidney, lung and brain. Highly expressed in adult pancreas, kidney, skeletal muscle, liver, lung, placenta, prostate, brain and heart.
  • 数据库链接：

    HGNC: 8045

    OMIM: 610325

    KEGG: hsa:10726

    STRING: 9606.ENSP00000319664

    UniGene: Hs.263812

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