Histone H2A type 1-B/E Recombinant Monoclonal Antibody

中文名称：

组蛋白 H2A type 1-B/E重组抗体
货号：

CSB-RA010385A0HU
规格：

￥1320
图片：
Western Blot
Positive WB detected in HepG2 whole cell lysate
All lanes Histone H2A type 1-B/E antibody at 2.7μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 13 KDa
Observed band size: 13 KDa

Immunofluorescence staining of Hela cells with CSB-RA010385A0HU at 1:168,counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4℃.The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG (H+L).
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产品描述：

CSB-RA010385A0HU是一种特异性识别组蛋白H2A亚型的高纯度抗体，靶向高度保守的组蛋白H2A家族成员。该抗体通过重组技术制备，具有批次间一致性优势，适用于多种实验场景。经严格验证，其在Western Blot中可特异性识别目标蛋白，推荐稀释比例为1:500-1:5000；在免疫荧光（IF）实验中能清晰定位细胞核内靶标，推荐稀释比例为1:30-1:200，同时适用于ELISA检测。作为核小体核心成分，H2A在染色质组装、DNA损伤修复及表观遗传调控中发挥关键作用，本产品可支持染色质结构分析、基因表达调控机制研究以及细胞周期相关实验。其高灵敏度和低交叉反应性特点使其成为表观遗传学、分子生物学及细胞生物学领域基础研究的可靠工具。
Uniprot No.：

P04908
基因名：

HIST1H2AB
别名：

H2a 615 antibody; H2A antibody; H2A GL101 antibody; H2A histone family member A antibody; H2A.1 antibody; H2A.2 antibody; H2A/a antibody; H2A/m antibody; H2A/O antibody; H2A/q antibody; H2A1B_HUMAN antibody; H2AFA antibody; H2AFE antibody; H2AFL antibody; H2AFM antibody; H2AFO antibody; H2AFQ antibody; HIST1H2AE antibody; HIST1H2AJ antibody; HIST2H2AA antibody; HIST2H2AA3 antibody; HIST2H2AB antibody; HIST2H2AC antibody; Histone 1 H2ae antibody; Histone 2 H2aa3 antibody; Histone 2 H2ab antibody; Histone 2 H2ac antibody; Histone H2A type 1 B antibody; Histone H2A type 1 C antibody; Histone H2A type 1 E antibody; Histone H2A type 1 J antibody; Histone H2A type 1-B/E antibody; Histone H2A.2 antibody; Histone H2A/a antibody; Histone H2A/m antibody; MGC74460 antibody
反应种属：

Human
免疫原：

A synthesized peptide
免疫原种属：

Homo sapiens (Human)
标记方式：

Non-conjugated
克隆类型：

Monoclonal
抗体亚型：

Rabbit IgG
纯化方式：

Affinity-chromatography
克隆号：

1H12
浓度：

It differs from different batches. Please contact us to confirm it.
保存缓冲液：

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
产品提供形式：

Liquid
应用范围：

ELISA, WB, IF
推荐稀释比：

Application Recommended Dilution

WB 1:500-1:5000

IF 1:30-1:200
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunofluorescence (IF) Protocol
储存条件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
货期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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功能：

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
亚细胞定位：

Nucleus. Chromosome.
蛋白家族：

Histone H2A family
数据库链接：

HGNC: 4734

OMIM: 602786

KEGG: hsa:3012

STRING: 9606.ENSP00000303373

UniGene: Hs.121017

Histone H2A type 1-B/E Recombinant Monoclonal Antibody

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Application	Recommended Dilution
WB	1:500-1:5000
IF	1:30-1:200