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  4. Histone H1.0 Recombinant Monoclonal Antibody

Histone H1.0 Recombinant Monoclonal Antibody

说明书
  • 中文名称：
    组蛋白 H1.0重组抗体
  • 货号：
    CSB-RA010087A0HU
  • 规格：
    ￥1320
  • 其他：

产品详情

  • 产品描述：
    CSB-RA010087A0HU 是一款针对核心连接组蛋白H1.0设计的高特异性科研抗体。该靶蛋白作为染色质结构的关键调控因子，通过参与核小体间连接维持基因组稳定性，并在细胞分化、基因沉默及表观遗传调控中发挥重要作用。本产品经ELISA平台严格验证，展现优异的抗原结合能力与批次间一致性，可精准识别天然构象的Histone H1.0蛋白。其重组单克隆抗体技术确保低交叉反应性和高重复性，适用于染色质动态分析、表观遗传修饰研究、基因表达谱解析等基础科研领域，尤其在探索细胞周期调控、干细胞分化机制及肿瘤发生相关染色质重塑过程中具有重要应用价值，为核蛋白功能研究和表观遗传学模型构建提供可靠工具。
  • Uniprot No.：
    P07305
  • 基因名：
    H1F0
  • 别名：
    H1 histone family member 0 antibody; H1(0) antibody; H10 antibody; H10_HUMAN antibody; h1f0 antibody; H1FV antibody; Histone H1'' antibody; Histone H1(0) antibody; Histone H1.0 antibody; Histone H10 antibody; Histone H5 antibody; MGC5241 antibody; N-terminally processed antibody
  • 反应种属：
    Human
  • 免疫原：
    A synthesized peptide
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Monoclonal
  • 抗体亚型：
    Rabbit IgG
  • 纯化方式：
    Affinity-chromatography
  • 克隆号：
    1C7
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
    ELISA Protocol
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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H1F0 antibodies

H1F0 Proteins

靶点详情

  • 功能：
    Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. The histones H1.0 are found in cells that are in terminal stages of differentiation or that have low rates of cell division.
  • 基因功能参考文献：
    1. H1.X moves more rapidly than other linker histones in vivo Domain swapping between H1.0 and H1.X suggests that the globular domain (GD) and C-terminal domain (CTD) of H1.X independently contribute to the dynamic behavior of H1.X. PMID: 27528617
    2. this study shows that dynamic epigenetic states defined by the linker histone H1.0 determine which cells within a tumor can sustain the long-term cancer growth. PMID: 27708074
    3. The N-terminal domain contributes toward the differential chromatin binding affinity, whereas the C-terminal domain contributes toward distinct nucleosomal interface of isotypes H10 and H1c. PMID: 22334665
    4. nuclear transport of H1 histones requires a heterodimeric nuclear import receptor PMID: 12080050
    5. H1(0)histone may be an important factor in normal DC differentiation. Tumor-derived factors may inhibit DC differentiation by affecting H1(0) expression. PMID: 12149419

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  • 亚细胞定位：
    Nucleus. Chromosome. Note=The RNA edited version has been localized to nuclear speckles. During mitosis, it appears in the vicinity of condensed chromosomes.
  • 蛋白家族：
    Histone H1/H5 family
  • 数据库链接：

    HGNC: 4714

    OMIM: 142708

    KEGG: hsa:3005

    STRING: 9606.ENSP00000344504

    UniGene: Hs.745024

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