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  4. GPA33 Recombinant Monoclonal Antibody

GPA33 Recombinant Monoclonal Antibody

说明书
  • 中文名称：
    GPA33重组抗体
  • 货号：
    CSB-RA245537A0HU
  • 规格：
    ￥1320
  • 图片：
    • IHC image of CSB-RA245537A0HU diluted at 1:100 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
    • IHC image of CSB-RA245537A0HU diluted at 1:100 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
  • 其他：

产品详情

  • 产品描述：
    CSB-RA245537A0HU GPA33重组单克隆抗体是针对人源糖蛋白A33（GPA33）设计的高特异性科研工具。GPA33作为一种跨膜糖蛋白，在正常胃肠道上皮细胞和结直肠癌等肿瘤组织中特异性表达，其参与细胞间粘附及信号调控的功能使其成为胃肠道肿瘤微环境研究的重要靶点。本抗体采用重组技术制备，经ELISA和免疫组化（IHC）双重验证，在IHC应用中推荐使用1:50至1:200的稀释比例，能清晰显示石蜡包埋组织中靶蛋白的定位与表达水平，背景信号低且重复性优异。该产品适用于胃肠道肿瘤病理学分析、肿瘤标志物筛选及细胞膜表面蛋白功能研究，可为探索GPA33在肿瘤发生发展中的分子机制、评估肿瘤组织特异性表达模式提供可靠支持，同时满足体外实验中对蛋白互作及信号通路研究的精准检测需求。
  • Uniprot No.：
    Q99795
  • 基因名：
    GPA33
  • 别名：
    Cell surface A33 antigen (Glycoprotein A33), GPA33
  • 反应种属：
    Human
  • 免疫原：
    A synthesized peptide derived from human GPA33
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Monoclonal
  • 抗体亚型：
    Rabbit IgG
  • 纯化方式：
    Affinity-chromatography
  • 克隆号：
    4H4
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:50-1:200
  • Protocols：
    ELISA Protocol
    Immunohistochemistry (IHC) Protocol
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

产品评价

相关产品

GPA33 antibodies

GPA33 Proteins

靶点详情

  • 功能：
    May play a role in cell-cell recognition and signaling.
  • 基因功能参考文献：
    1. A33 shows similar sensitivity to but is more specific than CDX2 as an immunomarker of colorectal carcinoma PMID: 28226180
    2. A33 expression is directly correlated to colorectal tumor differentiation. PMID: 27272411
    3. Data indicate that EpCAM- and A33-Exos were released from the apical and basolateral surfaces, respectively. PMID: 23230278
    4. Data indicate positive staining was observed for both A33 expression and KRN330 binding from patients biopsied on Day 8, 9 or 14 following initial dosing of 3 mg/kg. PMID: 23294608
    5. The A33-dependent incorporation of B5 into extracellular enveloped vaccinia virions is mediated through an interaction between their lumenal domains. PMID: 22623777
    6. Increased interaction between vaccinia virus proteins A33 and B5 is detrimental to infectious extracellular enveloped virion production. PMID: 22623782
    7. cloning, chromosomal localizations, exon-intron structures and transcription start sites - target gene for the intestine-specific homeobox transcription factor, CDX1. PMID: 12114523
    8. Regulation of A33 antigen expression by GKLF. PMID: 12853980
    9. This work has demonstrated that the antigen is both highly immobile and extremely persistent-retaining its surface localization for a turnover halflife of greater than 2 days. PMID: 18236042

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  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein.
  • 组织特异性：
    Expressed in normal gastrointestinal epithelium and in 95% of colon cancers.
  • 数据库链接：

    HGNC: 4445

    OMIM: 602171

    KEGG: hsa:10223

    STRING: 9606.ENSP00000356842

    UniGene: Hs.651244

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