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  4. FNTB Recombinant Monoclonal Antibody

FNTB Recombinant Monoclonal Antibody

说明书
  • 中文名称：
    FNTB重组抗体
  • 货号：
    CSB-RA267691A0HU
  • 规格：
    ￥1320
  • 图片：
    • Western Blot
      Positive WB detected in: 293 whole cell lysate, HepG2 whole cell lysate, Hela whole cell lysate, K562 whole cell lysate, Rat brain tissue
      All lanes: FNTB antibody at 1:2000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 49, 44 kDa
      Observed band size: 49 kDa
    • IHC image of CSB-RA267691A0HU diluted at 1:100 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
    • Immunoprecipitating FNTB in K562 whole cell lysate
      Lane 1: Rabbit control IgG instead of CSB-RA267691A0HU in K562 whole cell lysate. For western blotting,a HRP-conjugated Protein G antibody was used as the secondary antibody (1/2000)
      Lane 2: CSB-RA267691A0HU(2µg)+ K562 whole cell lysate(500µg)
      Lane 3: K562 whole cell lysate (10µg)
  • 其他：

产品详情

  • 产品描述：
    CSB-RA267691A0HU FNTB重组单克隆抗体是针对法尼基转移酶β亚基（FNTB）研发的高特异性检测工具。FNTB作为法尼基转移酶复合体的关键催化亚基，通过介导Ras等蛋白的法尼基化修饰参与细胞增殖与信号转导调控，其异常表达与多种肿瘤发生发展密切相关。本产品经多种平台严格验证：在Western Blot中可清晰识别天然及重组FNTB蛋白，呈现单一特异性条带；免疫组化实验显示其在组织切片中具有精准的亚细胞定位能力；免疫共沉淀验证证实其能高效富集内源性FNTB及其互作蛋白。推荐使用稀释度覆盖WB（1:500-5000）、IHC（1:50-200）及IP（1:200-1000）等多种实验体系，适用于癌症分子机制研究、蛋白质翻译后修饰分析以及靶向法尼基化通路药物的体外筛选等科研场景。该抗体具有批次稳定性高、交叉反应性低的特点，为探索FNTB在细胞信号网络中的功能及其病理学意义提供了可靠工具。
  • Uniprot No.：
    P49356
  • 基因名：
    FNTB
  • 别名：
    Protein farnesyltransferase subunit beta (FTase-beta) (EC 2.5.1.58) (CAAX farnesyltransferase subunit beta) (Ras proteins prenyltransferase subunit beta), FNTB
  • 反应种属：
    Human, Rat
  • 免疫原：
    A synthesized peptide derived from human FNTB
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Monoclonal
  • 抗体亚型：
    Rabbit IgG
  • 纯化方式：
    Affinity-chromatography
  • 克隆号：
    5H4
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IP
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:50-1:200
    IP 1:200-1:1000
  • Protocols：
    ELISA Protocol
    Western Blotting (WB) Protocol
    Immunohistochemistry (IHC) Protocol
    Immunoprecipitation (IP) Protocol
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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FNTB antibodies

FNTB Proteins

靶点详情

  • 功能：
    Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X.
  • 蛋白家族：
    Protein prenyltransferase subunit beta family
  • 数据库链接：

    HGNC: 3785

    OMIM: 134636

    KEGG: hsa:100529261

    STRING: 9606.ENSP00000246166

    UniGene: Hs.325531

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