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  4. ENPEP Recombinant Monoclonal Antibody

ENPEP Recombinant Monoclonal Antibody

说明书
  • 中文名称：
    ENPEP重组抗体
  • 货号：
    CSB-RA552900A0HU
  • 规格：
    ￥1320
  • 图片：
    • IHC image of CSB-RA552900A0HU diluted at 1:100 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
  • 其他：

产品详情

  • 产品描述：
    ENPEP Recombinant Monoclonal Antibody（CSB-RA552900A0HU）是一款针对人源谷氨酰氨肽酶（ENPEP）的高特异性抗体，适用于酶联免疫吸附实验（ELISA）和免疫组织化学（IHC）检测。ENPEP是一种膜结合金属蛋白酶，参与血管紧张素代谢和细胞黏附过程，其表达水平与血管生成、肿瘤微环境调控及心血管功能密切相关。本产品通过重组表达技术制备，经严格验证可在IHC实验中清晰显示ENPEP蛋白在石蜡包埋组织中的定位分布，推荐使用稀释比例为1:50-1:200，实验数据表明其具有优异的批间一致性、低交叉反应性和高信噪比特性，能够有效识别天然构象的靶蛋白。该抗体适用于研究ENPEP在组织发育、肿瘤生物学或心血管疾病相关模型中的表达调控机制，为探索其在细胞外基质重塑、病理微环境调控等领域的生物学功能提供可靠工具，满足基础科研中对蛋白定位及表达水平分析的需求。
  • Uniprot No.：
    Q07075
  • 基因名：
    ENPEP
  • 别名：
    Glutamyl aminopeptidase (EAP) (EC 3.4.11.7) (Aminopeptidase A) (AP-A) (Differentiation antigen gp160) (CD antigen CD249), ENPEP
  • 反应种属：
    Human
  • 免疫原：
    A synthesized peptide derived from human Aminopeptidase A / CD249
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Monoclonal
  • 抗体亚型：
    Rabbit IgG
  • 纯化方式：
    Affinity-chromatography
  • 克隆号：
    2G11
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:50-1:200
  • Protocols：
    ELISA Protocol
    Immunohistochemistry (IHC) Protocol
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

产品评价

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ENPEP antibodies

ENPEP Proteins

靶点详情

  • 功能：
    Regulates central hypertension through its calcium-modulated preference to cleave N-terminal acidic residues from peptides such as angiotensin II.
  • 基因功能参考文献：
    1. We suggest that APA enzymatic activity affects tumor initiation and cancer malignancy in a TWIST-dependent manner PMID: 28177885
    2. The substrate Angiotensin II, the enzymes aminopeptidases-A, B, M as well as IRAP were detected in the jejunal mucosa. PMID: 26311161
    3. This study suggests a role for GAP in the neoplastic development of renal tumours and provides additional data for considering the activity and expression of this enzyme of interest in the diagnosis and prognosis of renal neoplasms. PMID: 24885240
    4. These results explain the calcium-modulated substrate specificity of APA in central hypertension regulation PMID: 23888046
    5. There was no significant alteration in plasma APA activity in the patients with Chagas disease or dilated cardiomyopathies, as compared with that in health controls PMID: 21697726
    6. Rieger syndrome with microdeletions including only the PITX2 and ENPEP (glutamyl aminopeptidase) genes. PMID: 17850355
    7. Data show that APA appears to be an essential enzyme in the control of blood pressure via degradation of Angiotensin II. PMID: 17990103
    8. Data show that aminopeptidase A (APA) plays important roles in the regulation of blood pressure under both the physiological and pathological conditions. PMID: 17999179
    9. Data show that brain aminopeptidases act upon Ang I, Ang II and Ang III in order to activate brain AT(1) receptors. PMID: 18188697
    10. rare and common variation in ENPEP may contribute to the development of renal and hypertensive disorders and warrants further study PMID: 18206321
    11. The presence of APA in several human brain nuclei sensitive to angiotensins and involved in blood pressure regulation suggests that APA in humans is an integral component of the brain renin angiotensin system. PMID: 18410507
    12. A novel nonsense polymorphism in the aminopeptidase-a gene was associated with hypertension among postmenopausal women, and those with marginal calcium and vitamin D intake. PMID: 18550936
    13. Angiotensin III and aminopeptidase A and N, related converting enzymes, contribute to cell proliferation of prostate cancer and may be implicated in cancer progression. PMID: 18677709
    14. Over-expressed APA drastically reduces, in a calcium dependent manner, full-length-Abeta but not amyloid-beta precursor protein (APP) intracellular domain in a cell-free model of Abeta production. PMID: 19187443
    15. The activity of glutamyl aminopeptidase was significally increased in head and neck squamous cell carcinoma tissue. PMID: 19373777

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  • 亚细胞定位：
    Cell membrane; Single-pass type II membrane protein.
  • 蛋白家族：
    Peptidase M1 family
  • 组织特异性：
    Expressed in choriocarcinoma cancer cell lines (at protein level). Expressed by epithelial cells of the proximal tubule cells and the glomerulus of the nephron. Also found in a variety of other tissues.
  • 数据库链接：

    HGNC: 3355

    OMIM: 138297

    KEGG: hsa:2028

    STRING: 9606.ENSP00000265162

    UniGene: Hs.435765

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