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  4. CTSS Recombinant Monoclonal Antibody

CTSS Recombinant Monoclonal Antibody

说明书
  • 中文名称：
    CTSS重组抗体
  • 货号：
    CSB-RA788455A0HU
  • 规格：
    ￥1320
  • 图片：
    • IHC image of CSB-RA788455A0HU diluted at 1:100 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
    • IHC image of CSB-RA788455A0HU diluted at 1:100 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
  • 其他：

产品详情

  • 产品描述：
    CTSS Recombinant Monoclonal Antibody（CSB-RA788455A0HU）是一款针对组织蛋白酶S（Cathepsin S，CTSS）靶点开发的高特异性重组抗体。CTSS作为半胱氨酸蛋白酶家族成员，在抗原呈递、细胞外基质重塑及免疫调控中发挥关键作用，其异常表达与自身免疫性疾病、肿瘤进展及炎症反应密切相关。本抗体经ELISA和免疫组化（IHC）技术严格验证，在IHC应用中表现出优异的组织定位能力，推荐使用稀释比为1:50-1:200，可清晰检测福尔马林固定石蜡包埋样本中CTSS的胞内表达分布，且背景信号低、重复性好。其重组单克隆特性确保了高批次间一致性，适用于免疫学研究中的靶蛋白定量分析、疾病模型组织切片染色及肿瘤微环境相关机制探索。该产品为解析CTSS在免疫调节、神经退行性病变及心血管疾病中的功能研究提供了可靠工具，尤其适合在体外实验及病理学研究中用于蛋白表达水平与亚细胞定位的精准检测。
  • Uniprot No.：
    P25774
  • 基因名：
    CTSS
  • 别名：
    Cathepsin S (EC 3.4.22.27), CTSS
  • 反应种属：
    Human
  • 免疫原：
    A synthesized peptide derived from human Cathepsin S
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Monoclonal
  • 抗体亚型：
    Rabbit IgG
  • 纯化方式：
    Affinity-chromatography
  • 克隆号：
    9B10
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:50-1:200
  • Protocols：
    ELISA Protocol
    Immunohistochemistry (IHC) Protocol
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

产品评价

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靶点详情

  • 功能：
    Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules and MHC class II antigen presentation. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L.
  • 基因功能参考文献：
    1. Plasma apoA-I proteolysis is augmented in aortic valve stenosis and cathepsin S exerts the most deleterious effects on apoA-I integrity in humans. PMID: 29915952
    2. The present data indicating that Cat-S activity increases with CKD progression suggest that Cat-S might be a therapeutic target to prevent cardiovascular complications in CKD. PMID: 28240259
    3. High expression of CTSS was independently associated with lymph node metastasis (OR, 2.015; 95% CI, 1.225-3.315; P=0.006). Therefore, CTSS may serve as a predictive risk marker for the progression and prognosis of papillary thyroid cancer . PMID: 29749483
    4. Authors show a significant increase of circulating CS levels in healthy female subjects induced by long-term physical activity. PMID: 29181829
    5. This study therefore considerably improves our understanding of the molecular mechanism responsible for cathepsin S inhibition and facilitates the identification of potential novel selective inhibitors of cathepsin S. PMID: 28236030
    6. cathepsin S is increased in periodontal cells and tissues under inflammatory and infectious conditions, suggesting a critical role of this autophagy-associated molecule in the pathogenesis of periodontitis. PMID: 29362520
    7. Elevated cathepsin S activity was associated with collagen I degradation and thus might be involved in the progression of abdominal aortic aneurysms. PMID: 29624112
    8. Cathepsin S was identified as the major IL-36gamma-activating protease expressed in epithelial cells. PMID: 28289191
    9. Our results indicate that autophagy is essential for decreasing CTSS activity to inhibit tumor metastasis by hispolon treatment in cervical cancer; this finding provides a new perspective on molecular regulation. PMID: 28981104
    10. These results revealed that CTSS can regulate EGFR signalling by facilitating EGF-mediated EGFR degradation. PMID: 27387133
    11. This study suggested serum Cat S may be a potential biomarker for the diagnosis and prognosis of gastric cancer PMID: 27058412
    12. Overall, these results indicate that exploitation of the cathepsin S activity in MPS tissues can be utilized to substantially lower non-target accumulation, suggesting this is a promising approach for the development of diagnostic and radiotherapeutic nanomedicine platforms. PMID: 27372424
    13. polymorphism of rs7534124 and rs1136774 in cathepsin S promoter may decrease the susceptibility of asthma in a Chinese Han population PMID: 27249607
    14. cathepsin S mRNA (CTSS), which encodes a cysteine protease associated with angiogenesis and atherosclerosis, is highly edited in human endothelial cells. RNA editing enables the recruitment of the stabilizing RNA-binding protein human antigen R (HuR; encoded by ELAVL1) to the 3' UTR of the CTSS transcript, thereby controlling CTSS mRNA stability and expression. PMID: 27595325
    15. the essential role of autophagy-regulated early ROS in triggering late apoptotic signaling PMID: 26029922
    16. Cathepsin S cleaves near the N-terminus of PAR2 to expose a novel tethered ligand, KVDGTS. PMID: 24964046
    17. Increased plasma CTSS concentration is associated with atherogenesis. PMID: 24727728
    18. potential marker of pruritus in dandruff/seborrhoeic dermatitis PMID: 24690038
    19. results identify Cat-S as a biased agonist of PAR2 that causes PAR2- and TRPV4-dependent inflammation and pain. PMID: 25118282
    20. Its stability at neutral pH and potent proteolytic activity on extracellular matrix components mean that cathepsin S may contribute significantly to cartilage degradation and may thus be considered a potential drug target in joint diseases. PMID: 23152404
    21. High cathepsin S expression at the primary site correlates with decreased brain metastasis-free survival in breast cancer patients. PMID: 25086747
    22. cathepsin S and chemerin only correlated positively with insulin resistance and inflammation PMID: 24390241
    23. Cat S-mediated autophagic flux is an important mechanism for inducing M2-type polarization of tumor-associated macrophages, which leads to tumor development PMID: 24580730
    24. Cathepsin S plays an important role in the regulation of autophagy and apoptosis in human glioblastoma cells. PMID: 24875536
    25. Suppression of CD47 by morpholino approach suppressed growth of hepatocellular carcinoma in vivo and exerted a chemosensitization effect through blockade of CTSS/PAR2 signaling. PMID: 24523067
    26. The miR-31/IRF-1/CTSS pathway may play a functional role in the pathogenesis of cystic fibrosis lung disease. PMID: 24940638
    27. Markedly high levels of tear CTSS activity are suggestive of Sjogren syndrome. PMID: 24644101
    28. This study reveals a noncanonical molecular pathway in which, after the inhibition of cathepsin S, autophagy induces early reactive oxygen species production for oxidative DNA damage and cell death through xanthine oxidase. PMID: 23892358
    29. Amyloid-beta can regulate the proinflammatory state of human macrophages by inducing MMP-2/MMP-9/cathepsin S levels and by reducing TGF-beta1 secretion. PMID: 24335416
    30. Cat S may participate in the pathophysiology of cystic fibrosis by weakening the antibacterial activity of SP-A. PMID: 23707200
    31. the genetic polymorphisms of CTSS were associated with metabolic disorders in a Chinese Han population PMID: 23747398
    32. Cathepsin S activity appears to be involved in the early dysregulation of glucose and insulin metabolism. PMID: 22923671
    33. Cleavage of nidogen-1 by cathepsin S impairs its binding to basement membrane partners PMID: 22952693
    34. The present study was designed to determine the role of Cat S in human hepatocellular carcinoma cell growth, invasion and angiogenesis, using RNA interference technology. PMID: 22796222
    35. CTSS variants seem to be nominally associated to obesity related traits and this association may be modified by dietary protein intake PMID: 22844403
    36. HCV has an inhibitory role on cathepsin S-mediated major histocompatibility complex (MHC) class II maturation, which may contribute to weak immunogenicity of viral antigens in chronic infections. PMID: 22761382
    37. Cathepsin S therefore appears to be an important factor that influences selection of autoreactive T cells. PMID: 22424724
    38. Cathepsin S specificity profile appears to be pH-independent. PMID: 21967108
    39. Cathepsin S plays an important role in the regulation of cell autophagy through interference with the EGFR-ERK/MAPK-signaling pathway. PMID: 22101325
    40. results signify that CatS may be an important prognostic biomarker and predictive of response to adjuvant fluoruracil/folinic acid in colorectal carcinoma PMID: 21989182
    41. The cathepsin S deserves further evaluation as therapeutic targets to develop disease modifying drugs to treat Alzheimer's disease. PMID: 21585286
    42. Serum cathepsin S showed significantly lower values 4 days after surgery PMID: 21250859
    43. Among elderly individuals in 2 independent cohorts, higher serum cathepsin S levels were associated with increased mortality risk PMID: 21878432
    44. results suggest that CTSS mediated atherogenesis may be associated with a CD40 mediated inflammatory and immune response. Further invasive atheroma analysis is reasonable PMID: 21223957
    45. Cathepsin S activity in human whole blood was dependent on the time of blood collection, suggesting that cathepsin S activity is subject to circadian variations. PMID: 21094118
    46. Our data provide first evidence that Cathepsin S expression is selectively induced in psoriatic keratinocytes. PMID: 19849712
    47. Down-regulation of cathepsin S was found in inverted papilloma tissues as compared with its expression level in normal sinus mucosa tissues. PMID: 21038029
    48. the immunosuppressive effects of IL-10-STAT3 on MHC-II antigen presentation may occur via the inhibition of cathepsin S expres PMID: 20356901
    49. The researchers found no evidence of an association between the CTSS -25G/A polymorphism and the presence of coronary artery disease in a Chinese population. PMID: 19593952
    50. cathepsin S was found to be significantly elevated in rheumatoid arthritis and osteoarthritis synovial fluid. PMID: 20180636

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  • 亚细胞定位：
    Lysosome. Secreted. Cytoplasmic vesicle, phagosome.
  • 蛋白家族：
    Peptidase C1 family
  • 数据库链接：

    HGNC: 2545

    OMIM: 116845

    KEGG: hsa:1520

    STRING: 9606.ENSP00000357981

    UniGene: Hs.181301

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