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  4. VSIG4 Recombinant Monoclonal Antibody

VSIG4 Recombinant Monoclonal Antibody

说明书
  • 中文名称：
    VSIG4重组抗体
  • 货号：
    CSB-RA896869MA1HU
  • 规格：
    ￥1320
  • 图片：
    • The Binding Activity of VSIG4 with anti-VSIG4 antibody
      Activity: Measured by its binding ability in a functional ELISA. Immobilized Human VSIG4(CSB-MP896869HU) at 2 μg/ml can bind Anti-VSIG4 recombinant antibody, the EC50 is 51.14-68.73 ng/mL.
  • 其他：

产品详情

  • 产品描述：
    CSB-RA896869MA1HU是针对VSIG4（V-set and immunoglobulin domain-containing 4）靶点开发的重组单克隆抗体，适用于ELISA检测。该抗体通过重组蛋白表达系统制备，具有高批次间一致性和特异性，能够精准识别VSIG4分子。VSIG4作为B7家族共抑制分子成员，主要表达于组织驻留型巨噬细胞，通过调控T细胞活性参与免疫稳态维持，其异常表达与自身免疫性疾病、肿瘤免疫逃逸及炎症性疾病密切相关。经实验验证，本产品在ELISA平台中展现出优异的线性检测范围和低交叉反应性，适用于体外分析VSIG4蛋白表达水平，为研究其在免疫抑制微环境中的作用机制、探索慢性炎症疾病模型中的免疫调控网络，以及评估肿瘤相关巨噬细胞功能等基础科研领域提供可靠工具。本品仅限科学研究使用，不适用于临床诊断或其他用途。
  • Uniprot No.：
    Q9Y279
  • 基因名：
    VSIG4
  • 别名：
    Complement receptor of the immunoglobulin superfamily antibody; CRIg antibody; Ig superfamily protein antibody; Protein Z39Ig antibody; UNQ317/PRO362 antibody; V set and immunoglobulin domain containing 4 antibody; V-set and immunoglobulin domain-containing protein 4 antibody; VSIG4 antibody; VSIG4_HUMAN antibody; Z39IG antibody
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human VSIG4 protein
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Monoclonal
  • 抗体亚型：
    hIgG1
  • 纯化方式：
    Affinity-chromatography
  • 克隆号：
    12D12
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
    ELISA Protocol
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

产品评价

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靶点详情

  • 功能：
    Phagocytic receptor, strong negative regulator of T-cell proliferation and IL2 production. Potent inhibitor of the alternative complement pathway convertases.
  • 基因功能参考文献：
    1. Soluble VSIG4 levels are associated with the progression and recurrence of ovarian cancer, indicating that soluble VSIG4 may be used as a potential biomarker for predicting tumor prognosis. PMID: 28498255
    2. VSIG4 signaling provides an anti-immune evasion mechanism that prevents the outgrowth of intracellular bacteria in macrophages PMID: 27440002
    3. The VSIG4 upregulation by LMP1 was regulated at the transcriptional level via the NF-kB signaling axis. PMID: 28859984
    4. VSIG4 expression is significantly upregulated in human masticatory mucosa during wound healing PMID: 28005267
    5. we concluded that let-7g-5p inhibits epithelial-mesenchymal transition (EMT) consistent with reduction of glioma stem cell (GSC) phenotypes by targeting VSIG4 in glioblastoma. PMID: 27634309
    6. Data indicate that rotein kinase calpha (PKCalpha) plays a role in downregulating complement receptor Ig (CRIg coded by V-set and Ig domain-containing protein 4 VSIG4) expression. PMID: 25687755
    7. complement receptor of the immunoglobulin superfamily-L-factor H protects glomerular mesangial cells from complement-mediated injury and proliferative lesions PMID: 25114177
    8. we identified VSIG4 as a potential diagnostic marker of severe preeclampsia. The determination of this gene may improve the prognostic assessment of severe preeclampsia. PMID: 24349325
    9. Data indicate that massive V-set and Ig domain-containing 4 VSIG4(+) cell infiltration throughout the non-small-cell lung cancer samples. PMID: 24862966
    10. we showed that a complement receptor of the Ig superfamily (CRIg, also known as Z39Ig), a receptor for complement fragments (C3b and iC3b), was expressed on a subset of intestinal macrophages in murine and human large intestine PMID: 21768202
    11. These results suggest that T cells can opposite T cell hyporesponsiveness through dampening Z39Ig inhibitory signals from macrophages and thus maintain their anti-viral function in chronic hepatitis B. PMID: 20399148
    12. hVSIG4 recombinant adenovirus-transfected DCs suppress T cell proliferation, cytokine production and activation marker expression with PMID: 19914289
    13. Results report the identification and characterization of a Complement Receptor of the Immunoglobulin superfamily, CRIg, that binds complement fragments C3b and iC3b. PMID: 16530040
    14. These data indicate that the macrophage Z39Ig is involved in the pathogenesis of inflammatory diseases through chemokine induction, which will promote the migration of inflammatory cells into the lesion area, and MMP-9 induction. PMID: 16882875
    15. The specific expression of VSIG4 on resting macrophages suggests that VSIG4 may be important for the maintenance of T cell unresponsiveness in healthy tissues. PMID: 17016562
    16. CRIg is not only a phagocytic receptor, but also a potent inhibitor of the alternative pathway convertases PMID: 17051150

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  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein.
  • 组织特异性：
    Abundantly expressed in several fetal tissues. In adult tissues, highest expression in lung and placenta. Expressed in resting macrophages.
  • 数据库链接：

    HGNC: 17032

    OMIM: 300353

    KEGG: hsa:11326

    STRING: 9606.ENSP00000363869

    UniGene: Hs.8904

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