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  4. TMEM192 Recombinant Monoclonal Antibody

TMEM192 Recombinant Monoclonal Antibody

说明书
  • 中文名称：
    TMEM192重组抗体
  • 货号：
    CSB-RA249639A0HU
  • 规格：
    ￥1320
  • 图片：
    • Western Blot
      Positive WB detected in: HepG2 whole cell lysate, PC-3 whole cell lysate, U251 whole cell lysate, MCF-7 whole cell lysate, A549 whole cell lysate
      All lanes: TMEM192 antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 31 kDa
      Observed band size: 31 kDa
    • IHC image of CSB-RA249639A0HU diluted at 1:100 and staining in paraffin-embedded human prostate tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.
  • 其他：

产品详情

  • 产品描述：
    CSB-RA249639A0HU TMEM192重组单克隆抗体是针对跨膜蛋白192（TMEM192）研发的高特异性科研工具，适用于蛋白质定位及功能机制研究。TMEM192作为溶酶体相关跨膜蛋白，在细胞器稳态维持、物质运输及代谢调控中发挥重要作用。该抗体经多种技术平台验证，在Western Blot（WB）中可识别天然状态靶蛋白，呈现单一清晰条带；免疫组化（IHC）实验显示其在多种组织样本中能精准定位TMEM192的亚细胞分布，染色结果呈现优异的分辨率和特异性。推荐使用稀释度为WB 1:500-1:2000，IHC 1:50-1:200，实验数据展现优异的批次间稳定性和重复性。本产品适用于探索溶酶体生物学功能、细胞器互作网络分析、以及疾病模型中跨膜蛋白异常表达研究等领域，为细胞生物学、分子病理学及代谢调控机制等基础研究提供可靠检测工具，严格限于体外实验及科学研究使用。
  • Uniprot No.：
    Q8IY95
  • 基因名：
    TMEM192
  • 别名：
    Transmembrane protein 192, TMEM192
  • 反应种属：
    Human
  • 免疫原：
    A synthesized peptide derived from human TMEM192
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Monoclonal
  • 抗体亚型：
    Rabbit IgG
  • 纯化方式：
    Affinity-chromatography
  • 克隆号：
    21G8
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:50-1:200
  • Protocols：
    ELISA Protocol
    Western Blotting (WB) Protocol
    Immunohistochemistry (IHC) Protocol
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

产品评价

相关产品

TMEM192 antibodies

TMEM192 Proteins

靶点详情

  • 基因功能参考文献：
    1. Authors found that transmembrane protein 192 (TMEM192) interacted with TIG1. Authors also found that both TIG1A and TIG1B isoforms interacted and co-localized with TMEM192 in HtTA cervical cancer cells. The expression of TIG1 induced the expression of autophagy-related proteins. PMID: 27989102
    2. TMEM192 deficiency can induce autophagy in tumor cells, and can further activate apoptosis by the mitochondrial pathway through autophagy. PMID: 22736246
    3. TMEM192 was found to be strongly expressed in human kidney, liver, lung and pancreas tissue. The widespread tissue distribution could suggest an important role of TMEM192 for lysosomal function. PMID: 20370317
  • 亚细胞定位：
    Lysosome membrane; Multi-pass membrane protein. Late endosome.
  • 蛋白家族：
    TMEM192 family
  • 组织特异性：
    Strongly expressed in kidney, liver, lung and pancreas.
  • 数据库链接：

    HGNC: 26775

    KEGG: hsa:201931

    STRING: 9606.ENSP00000305069

    UniGene: Hs.704511

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