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  4. SLC25A12 Recombinant Monoclonal Antibody

SLC25A12 Recombinant Monoclonal Antibody

说明书
  • 中文名称：
    SLC25A12重组抗体
  • 货号：
    CSB-RA912385A0HU
  • 规格：
    ￥1320
  • 图片：
    • Western Blot
      Positive WB detected in: U87 whole cell lysate, A549 whole cell lysate
      All lanes: SLC25A12 antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 75, 63 kDa
      Observed band size: 72-80 kDa
  • 其他：

产品详情

  • 产品描述：
    CSB-RA912385A0HU是针对SLC25A12靶点研发的重组单克隆抗体，适用于ELISA和Western Blot（WB）等实验场景。SLC25A12是线粒体溶质载体蛋白家族成员，作为钙结合天冬氨酸/谷氨酸载体，参与调控线粒体膜间代谢物转运及细胞能量代谢平衡，其功能异常与神经系统发育及线粒体相关疾病机制研究密切相关。本抗体通过重组表达技术制备，经严格验证可在WB实验中特异性识别天然及过表达的SLC25A12蛋白，推荐使用稀释比例为1:500至1:2000，实验结果显示清晰的目标条带且背景信号低，适用于检测多种哺乳动物细胞或组织样本。该产品可为研究线粒体代谢调控、神经元能量稳态及钙信号传导等领域的科研工作者提供可靠工具，支持包括蛋白表达分析、信号通路探索及分子互作研究在内的基础科研应用。
  • Uniprot No.：
    O75746
  • 基因名：
    SLC25A12
  • 别名：
    Calcium-binding mitochondrial carrier protein Aralar1 (Mitochondrial aspartate glutamate carrier 1) (Solute carrier family 25 member 12), SLC25A12, ARALAR1
  • 反应种属：
    Human
  • 免疫原：
    A synthesized peptide derived from human SLC25A12
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Monoclonal
  • 抗体亚型：
    Rabbit IgG
  • 纯化方式：
    Affinity-chromatography
  • 克隆号：
    10B12
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
  • Protocols：
    ELISA Protocol
    Western Blotting (WB) Protocol
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

产品评价

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SLC25A12 antibodies

SLC25A12 Proteins

靶点详情

  • 功能：
    Mitochondrial and calcium-binding carrier that catalyzes the calcium-dependent exchange of cytoplasmic glutamate with mitochondrial aspartate across the mitochondrial inner membrane. May have a function in the urea cycle.
  • 基因功能参考文献：
    1. Genetic variants of SLC25A12 may be associated with risks for childhood ASD. PMID: 28536923
    2. The features of AGC1 structure and function in physiology and pathology, regulation by calcium, dependency on mitochondrial membrane potential, role in cancer cells, and tissue specificity are reviewed. AGC1 is involved in the glutamate-mediated excitotoxicity in neurons and AGC gene or protein alterations were discovered in rare human diseases. Review. PMID: 27132995
    3. Sensitivity analyses including only studies with family-based design demonstrated significant association between autism spectrum disorders and SNPs rs2292813 and rs2056202. In contrast, sensitivity analyses including case-control design studies only failed to find a significant association. Review. PMID: 25663199
    4. rs2056202 and rs2292813 in SLC25A12 may contribute significantly to autism spectrum disorders risk. PMID: 25921325
    5. Structure of the calcium bound and calcium free N- and C-terminal domains is described, elucidating the mechanism of calcium regulation. PMID: 25410934
    6. The physiological roles of AGC1, its links to calcium homeostasis, and its involvement in autism pathogenesis, are reviewed. PMID: 21691713
    7. This study found no differences in the allele, genotype, or haplotype frequencies of these two SNPs between patients and controls. PMID: 19913066
    8. Variants of the AGC1-encoding SLC25A12 gene were neither correlated with AGC activation nor associated with autism-spectrum disorders in 309 simplex and 17 multiplex families. PMID: 18607376
    9. SLC25A12 gene is linked to autism PMID: 15056512
    10. Aralar1 has a role in determining glucose metabolic fate, mitochondrial activity, and insulin secretion in beta cells PMID: 15494407
    11. These results suggest that SLC25A12 is not a major contributor to autism risk in these families. PMID: 16648338
    12. it is unlikely that the SLC25A12 polymorphisms investigated play a substantial role in conferring susceptibility to schizophrenia PMID: 17693006
    13. rs2056202 polymorphism in SLC25A12 may be associated with levels of routines and rituals in autism and related disorders PMID: 17894412
    14. SLC25A12 expression is associated with neurite outgrowth and is upregulated in the prefrontal cortex of autistic subjects. PMID: 18180767
    15. SLC25A12 gene is associated with autism. PMID: 19360665

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  • 相关疾病：
    Epileptic encephalopathy, early infantile, 39 (EIEE39)
  • 亚细胞定位：
    Mitochondrion inner membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Mitochondrial carrier (TC 2.A.29) family
  • 组织特异性：
    Expressed predominantly in the heart and skeletal muscle, weakly in brain and kidney.
  • 数据库链接：

    HGNC: 10982

    OMIM: 603667

    KEGG: hsa:8604

    STRING: 9606.ENSP00000388658

    UniGene: Hs.470608

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