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  4. PLEKHA1 Recombinant Monoclonal Antibody

PLEKHA1 Recombinant Monoclonal Antibody

说明书
  • 中文名称：
    PLEKHA1重组抗体
  • 货号：
    CSB-RA918477A0HU
  • 规格：
    ￥1320
  • 图片：
    • Western Blot
      Positive WB detected in: Hela whole cell lysate, A549 whole cell lysate, PC-3 whole cell lysate, MCF-7 whole cell lysate
      All lanes: PLEKHA1 antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 46, 39 kDa
      Observed band size: 36-55 kDa
  • 其他：

产品详情

  • 产品描述：
    CSB-RA918477A0HU PLEKHA1重组单克隆抗体是针对人源PLEKHA1蛋白开发的高特异性检测工具。该抗体靶向的PLEKHA1（Pleckstrin Homology Domain Containing A1）是一种参与细胞间连接调控的关键分子，通过其PH结构域参与细胞极性维持和信号转导过程，在维持上皮组织屏障功能及肿瘤微环境调控中发挥重要作用。经严格验证，本抗体在Western Blot实验中可识别特异性条带，推荐工作浓度为1:500-1:2000，同时在ELISA平台中表现出良好的抗原结合能力。适用于研究细胞连接复合体动态变化、上皮-间质转化机制以及肿瘤细胞迁移等方向，特别推荐用于细胞裂解液或组织样本中PLEKHA1蛋白表达的定量及定性分析。该产品经过重组表达技术制备，具有批次间一致性高的特点，可为细胞生物学及肿瘤微环境相关研究提供稳定可靠的检测支持。
  • Uniprot No.：
    Q9HB21
  • 基因名：
    PLEKHA1
  • 别名：
    Pleckstrin homology domain-containing family A member 1 (PH domain-containing family A member 1) (Tandem PH domain-containing protein 1) (TAPP-1), PLEKHA1, TAPP1
  • 反应种属：
    Human
  • 免疫原：
    A synthesized peptide derived from human PLEKHA1
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Monoclonal
  • 抗体亚型：
    Rabbit IgG
  • 纯化方式：
    Affinity-chromatography
  • 克隆号：
    16C9
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
  • Protocols：
    ELISA Protocol
    Western Blotting (WB) Protocol
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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PLEKHA1 antibodies

PLEKHA1 Proteins

靶点详情

  • 功能：
    Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane.
  • 基因功能参考文献：
    1. investigated the association of PLEKHA1 958A/G, polymorphisms with Age-Related Macular Degeneration (AMD) risk. PLEKHA1 958A/G polymorphism was associated with a decreased AMD risk (additive model: aOR=0.722, 95% CI=0.450-0.979, P=0.019; allele model: aOR=0.883, 95% CI=0.736-0.992, P=0.014) PMID: 29565837
    2. Studies indicate that the high-risk allele of the 10q26 locus encompasses three genes, PLEKHA1, ARMS2, and HTRA1 with high linkage disequilibrium. PMID: 26427389
    3. CX3CR1 (T280M and V249I) and PLEKHA1 (A320T) polymorphisms were not found to be associated with age-related macular degeneration in an Indian population. PMID: 25050486
    4. This study provides evidence of the joint contribution of genetic variants in PLEKHA1/ARMS2/HTRA1 to age-related macular degeneration risk. PMID: 24013816
    5. TAPP1 binds to protein tyrosine phosphatase PTPL1. PMID: 14516276
    6. syntrophins regulate the localization of TAPP1, which may be important for remodeling the actin cytoskeleton in response to growth factor stimulation PMID: 15485858
    7. PLEKHA1 is strongly implicated as primarily responsible for the evidence of linkage of age-related maculopathy (ARM) to the 10q26 locus and as a major contributor to ARM.susceptibility. PMID: 16080115
    8. Although a role for PLEKHA1 could not be totally excluded, there was a four times higher age-related macular degeneration risk was associated with haplotype "A-T-A" involving "PLEKHA1-LOC387715-HTRA1" risk alleles. PMID: 18079691
    9. Independent of CFH genotype or smoking history, an individual's risk of AMD (age-related macular degeneration) could be increased or decreased, depending on their genotype or haplotype in the 10q26 region. PMID: 18164066

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  • 亚细胞定位：
    Cytoplasm. Cell membrane; Peripheral membrane protein. Nucleus.
  • 组织特异性：
    Highly expressed in skeletal muscle, thymus, pancreas, placenta and lung. Detected at low levels in brain, heart, peripheral blood leukocytes, testis, ovary, spinal cord, thyroid, kidney, liver, small intestine and colon.
  • 数据库链接：

    HGNC: 14335

    OMIM: 607772

    KEGG: hsa:59338

    STRING: 9606.ENSP00000357986

    UniGene: Hs.643512

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