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  4. MYL9 Recombinant Monoclonal Antibody

MYL9 Recombinant Monoclonal Antibody

说明书
  • 中文名称：
    MYL9重组抗体
  • 货号：
    CSB-RA015318MA1HU
  • 规格：
    ￥1320
  • 图片：
    • The Binding Activity of Human MYL9 with Anti-MYL9 recombinant antibody
      Activity: Measured by its binding ability in a functional ELISA. Immobilized Human MYL9 (CSB-YP015318HU) at 2 μg/mL can bind Anti-MYL9 recombinant antibody, the EC50 is 4.628-6.430 ng/mL.
    • The Binding Activity of Human MYL12B with Anti-MYL9 recombinant antibody
      Activity: Measured by its binding ability in a functional ELISA. Immobilized Human MYL12B (CSB-EP015308HUc7) at 2 μg/mL can bind Anti-MYL9 recombinant antibody, the EC50 is 7.760-8.646 ng/mL.
    • The Binding Activity of Human MYL12A with Anti-MYL9 recombinant antibody
      Activity: Measured by its binding ability in a functional ELISA. Immobilized Human MYL12A (CSB-EP015307HUc7) at 2 μg/mL can bind Anti-MYL9 recombinant antibody, the EC50 is 5.325-6.456 ng/mL.
  • 其他：

产品详情

  • 产品描述：
    CSB-RA015318MA1HU是靶向MYL9蛋白的重组单克隆抗体，专为科研实验设计。MYL9（肌球蛋白调节轻链9）是肌球蛋白轻链家族成员，在细胞收缩、迁移及细胞形态维持中发挥关键作用，尤其参与调控平滑肌和非肌肉细胞的收缩过程。本产品通过重组表达技术制备，经ELISA平台严格验证，展现出优异的抗原结合能力，具备高特异性与批次间稳定性，可满足精准检测需求。适用于探索细胞骨架动力学、血管张力调节、组织纤维化机制等基础研究领域，特别在心血管功能调控、细胞运动相关疾病模型的分子机制研究中具有应用价值，为深入解析细胞收缩信号通路提供可靠工具。该抗体不适用于临床诊断及治疗相关研究。
  • Uniprot No.：
    P24844
  • 基因名：
    MYL9
  • 别名：
    MYL9 Recombinant Monoclonal Antibody
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human MYL9 protein
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Monoclonal
  • 抗体亚型：
    hIgG2
  • 纯化方式：
    Affinity-chromatography
  • 克隆号：
    6G11
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
    ELISA Protocol
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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MYL9 antibodies

MYL9 Proteins

靶点详情

  • 功能：
    Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion. In myoblasts, may regulate PIEZO1-dependent cortical actomyosin assembly involved in myotube formation.
  • 基因功能参考文献：
    1. MYL9 expression might be a promising prognostic marker and therapeutic target in ESCC PMID: 28388691
    2. At the cleavage furrow Arv1 recruits myosin heavy chain 9 (MYH9) and myosin light chain 9 (MYL9) by interacting with IQ-motif-containing GTPase-activating protein (IQGAP1). PMID: 27104745
    3. These findings suggested that low MYLK and MYL9 expressions might be associated with the development of NSCLC. PMID: 25179839
    4. the decreased expression of MYL9 may play an important role in tumor progression of prostate cancer PMID: 24338276
    5. Overexpression of MRTF-A significantly promoted the migration of MCF-7 cells through its transactivation effects on MYL9 and CYR61 genes PMID: 24084383
    6. Overexpression of SMYD3 promotes MRTF-A-mediated upregulation of MYL9 and migration of MCF-7 breast cancer cells PMID: 24189459
    7. surface CD3 expression proceeds through both MYL9-dependent and MYL9-independent pathways (i.e. the protein kinase C- dependent pathway) in Jurkat cells. PMID: 23538510
    8. The FHC-mediated structural perturbations in RLC that affect Ca(2+) binding properties of mutated myocardium are responsible for triggering the abnormal function of the heart that in turn might initiate a hypertrophic process and lead to heart failure. PMID: 16076902
    9. Smooth muscle type isoform, MLC-2C, is the inducible isoform, and might play a crucial role in monocyte/macrophage cell lineage. PMID: 18480596
    10. use of a shRNA to decrease MYL9 expression showed that MYL9 was involved in proplatelet formation PMID: 19724058

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  • 亚细胞定位：
    Cytoplasm, cytoskeleton. Cytoplasm, cell cortex.
  • 组织特异性：
    Smooth muscle tissues and in some, but not all, nonmuscle cells.
  • 数据库链接：

    HGNC: 15754

    OMIM: 609905

    KEGG: hsa:10398

    STRING: 9606.ENSP00000279022

    UniGene: Hs.504687

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