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  4. MRAS Recombinant Monoclonal Antibody

MRAS Recombinant Monoclonal Antibody

说明书
  • 中文名称：
    MRAS重组抗体
  • 货号：
    CSB-RA014781MA1HU
  • 规格：
    ￥1320
  • 图片：
    • IHC image of CSB-RA014781MA1HU diluted at 1:600 and staining in paraffin-embedded human prostate tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-Mouse IgG labeled by HRP and visualized using 0.05% DAB.
    • Immunofluorescence staining of Hela cell with CSB-RA014781MA1HU at 1:200, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Mouse IgG(H+L).
  • 其他：

产品详情

  • 产品描述：
    CSB-RA014781MA1HU MRAS重组单克隆抗体是针对MRAS靶点研发的高特异性科研试剂，经ELISA、免疫组化（IHC）和免疫荧光（IF）等多平台严格验证，在IHC应用中推荐1:20-1:200稀释度，IF实验建议1:20-1:200稀释比例。该抗体通过抗原亲和力纯化工艺制备，展现出优异的靶标结合特异性，在多种组织样本中均能实现清晰的细胞膜/细胞质定位信号，且背景干扰低，重复性稳定。MRAS作为RAS癌基因家族成员，参与调控MAPK信号通路，在细胞增殖、分化及肿瘤发生发展中具有重要作用。本产品适用于探究MRAS在肿瘤微环境中的表达模式、癌症相关信号通路调控机制以及细胞功能研究，可配合病理学分析、分子互作实验及细胞模型构建，为肿瘤生物学基础研究提供精准的实验工具。
  • Uniprot No.：
    O14807
  • 基因名：
    MRAS
  • 别名：
    FLJ42964 antibody; M ras antibody; M-ras antibody; Mras antibody; Muscle and microspikes Ras antibody; Muscle RAS oncogene homolog antibody; Muscle Ras oncogene homologue antibody; Muscle Ras viral oncogene homolog antibody; R ras3 antibody; R-ras3 antibody; Ras related protein MRas antibody; Ras related protein RRas3 antibody; Ras-related protein M-Ras antibody; Ras-related protein R-Ras3 antibody; RASM_HUMAN antibody; Related Ras viral oncogene homolog 3 antibody; RRas3 antibody; XRas antibody
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human MRAS protein
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Monoclonal
  • 抗体亚型：
    Mouse IgG2a
  • 纯化方式：
    Affinity-chromatography
  • 克隆号：
    17H12
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:20-1:200
  • Protocols：
    ELISA Protocol
    Immunohistochemistry (IHC) Protocol
    Immunofluorescence (IF) Protocol
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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MRAS antibodies

MRAS Proteins

靶点详情

  • 功能：
    Serves as an important signal transducer for a novel upstream stimuli in controlling cell proliferation. Activates the MAP kinase pathway.
  • 基因功能参考文献：
    1. acute coronary syndrome in Czechs (30.4% vs 29.4% carriers of the minor T allele of MRAS[recessive model], p = 0.54; OR 1.05; 95% CI 0.89-1.24 for males and 32.1% vs 29.7% carriers of the minor T allele, p = 0.28; OR 1.12; 95% CI 0.91-1.37 for females) PMID: 29264877
    2. Results discovered for the first time that MRAS is recurrently mutated, indicating that MRAS mutations could drive tumorigenesis of Type IV gastric neoplasm. PMID: 27891760
    3. The association of the MARS rs6782181 polymorphism and serum lipid levels is different between the Mulao and Han populations, or between males and females in the both ethnic groups. PMID: 25973078
    4. The MRAS gene loci might have a minor effect in conferring susceptibility to coronary artery disease in the Chinese population. PMID: 25800439
    5. Both MRAS and SHOC2 play a key role in polarized migration. PMID: 24211266
    6. implicated in a novel pathway of neuronal differentiation by coupling specific trophic factors to the MAPK cascade through the activation of B-Raf PMID: 12138204
    7. These findings proved a crucial role of the cross-talk between two Ras-family GTPases M-Ras and Rap1, mediated by RA-GEF-2, in adhesion signaling. PMID: 17538012
    8. Identification of one new CAD risk locus on 3q22.3 in MRAS, and suggestive association with a locus on 12q24.31 near HNF1A-C12orf43. PMID: 19198612

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  • 亚细胞定位：
    Cell membrane; Lipid-anchor; Cytoplasmic side.
  • 蛋白家族：
    Small GTPase superfamily, Ras family
  • 组织特异性：
    Expression highly restricted to the brain and heart.
  • 数据库链接：

    HGNC: 7227

    OMIM: 608435

    KEGG: hsa:22808

    STRING: 9606.ENSP00000289104

    UniGene: Hs.527021

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