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CSN2 Recombinant Monoclonal Antibody

说明书
  • 中文名称：
    CSN2重组抗体
  • 货号：
    CSB-RA959139A0HU
  • 规格：
    ￥1320
  • 图片：
    • IHC image of CSB-RA959139A0HU diluted at 1:100 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.
    • IHC image of CSB-RA959139A0HU diluted at 1:100 and staining in paraffin-embedded human prostate cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.
    • Overlay Peak curve showing HepG2 cells stained with CSB-RA959139A0HU (red line) at 1:100. The cells were fixed in 4% formaldehyde (15min) and permeated by 0.2% TritonX-100 for 10min. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃.The secondary antibody used was FITC-conjugated Goat Anti-rabbit IgG(H+L) at 1:200 dilution for 35min at 4℃.Control antibody (green line) was rabbit IgG (1ug/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.
  • 其他：

产品详情

  • 产品描述：
    CSN2 Recombinant Monoclonal Antibody（Code: CSB-RA959139A0HU）是针对COP9信号体复合体亚基2（CSN2）研发的高特异性抗体，该靶点通过调控泛素-蛋白酶体系统参与细胞周期进程、DNA损伤修复及转录因子活性等关键生物学过程。本产品经ELISA、免疫组化（IHC）和流式细胞术（FC）等多平台严格验证，在IHC应用中可清晰显示组织或细胞样本中CSN2蛋白的定位与表达水平，推荐稀释比例为1:50-1:200；流式检测中同样表现出优异的信号分辨能力，推荐使用浓度范围为1:50-1:200。其重组单克隆特性确保了批次间的高度一致性，适用于探究CSN2在蛋白质稳定性调控、肿瘤发生机制及细胞应激反应中的功能研究，为发育生物学、癌症信号通路分析等基础科研领域提供可靠工具。本品仅供科学研究使用。
  • Uniprot No.：
    P05814
  • 基因名：
    CSN2
  • 别名：
    Beta-casein, CSN2, CASB
  • 反应种属：
    Human
  • 免疫原：
    A synthesized peptide derived from human CSN2
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Monoclonal
  • 抗体亚型：
    Rabbit IgG
  • 纯化方式：
    Affinity-chromatography
  • 克隆号：
    29D6
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, FC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:50-1:200
    FC 1:50-1:200
  • Protocols：
    ELISA Protocol
    Immunohistochemistry (IHC) Protocol
    Flow cytometry (FC) Protocol
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

产品评价

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CSN2 antibodies

CSN2 Proteins

靶点详情

  • 功能：
    Important role in determination of the surface properties of the casein micelles.
  • 基因功能参考文献：
    1. Data suggest that neurogenesis in neuronal stem cells is differentially affected by human and bovine beta-casein-derived opioid peptides BCM7 and BCM9; such neurogenic changes are accompanied by changes in glutathione/glutathione disulfide ratio and in S-adenosylmethionine/S-adenosylhomocysteine ratio, indicative of changes in redox and methylation states (including DNA methylation). PMID: 27611101
    2. Exogenous 5-HT decreased beta-casein expression in MCF-12A human mammary epithelial cells and was responsible for inhibiting phosphorylation of STAT5, resulting in a decline in lactational function. PMID: 25087955
    3. The acidic fragment of human Abeta (Abeta1-11) and a phosphorylated fragment of beta-Casein induced tau fibrillization in vitro. PMID: 24364857
    4. Milk congestion gives rise to higher levels of beta-casomorphin-8 in milk and plasma than in lactating women without problems. PMID: 24189037
    5. derivatives of peptide fragment (54-59) exhibit immunosuppressant activity PMID: 19463972
    6. New functions of lactoferrin and beta-casein in mammalian milk as cysteine protease inhibitors. They might play a role in antiseptic and antiinfectious functions due to cysteine protease inhibition of bacteria and viruses. PMID: 12788072
    7. The RCM-kappa does form concentration-dependent micelles. Also, beta-CN phosphorylation level influences micelle formation. Complexes were low-temperature reversible and RCM-kappa fibrils were seen. PMID: 16947075
    8. a negative cross talk between PR and Stat5a/GR may contribute to the physiological role of progesterone to repress lactogenic hormone induction of the beta-casein gene PMID: 16973758

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Beta-casein family
  • 组织特异性：
    Mammary gland specific. Secreted in milk.
  • 数据库链接：

    HGNC: 2447

    OMIM: 115460

    KEGG: hsa:1447

    STRING: 9606.ENSP00000341030

    UniGene: Hs.2242

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