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  4. CLEC9A Recombinant Monoclonal Antibody

CLEC9A Recombinant Monoclonal Antibody

说明书
  • 中文名称：
    CLEC9A Recombinant Monoclonal Antibody
  • 货号：
    CSB-RA740922MA1HU
  • 规格：
    ￥1320
  • 图片：
    • The Binding Activity of Human CLEC9A with Anti-CLEC9A recombinant antibody
      Activity: Measured by its binding ability in a functional ELISA. Immobilized Anti-CLEC9A recombinant antibody at 2 μg/mL can bind Human CLEC9A protein (CSB-MP740922HU-B). The EC50 is 2.915-3.520 ng/mL.
  • 其他：

产品详情

  • 产品描述：
    CLEC9A重组单克隆抗体（CUSABIO货号：CSB-RA740922MA1HU）是一款针对CLEC9A靶点设计的高特异性科研工具。CLEC9A是C型凝集素家族成员，主要表达于树突状细胞表面，通过识别死亡细胞释放的肌动蛋白相关分子参与抗原交叉提呈，在启动适应性免疫应答中发挥关键作用。本抗体经ELISA严格验证，推荐工作稀释度为1:5000至1:50000，可高效识别天然构象下的靶蛋白，展现优异的灵敏度和低背景特性。适用于体外实验中对CLEC9A蛋白的定量检测、免疫调控机制研究以及树突状细胞相关功能分析，为免疫学、肿瘤微环境研究及感染性疾病模型构建提供可靠支持。该产品采用重组单克隆抗体技术，确保批次间一致性，适用于需要高重复性的实验体系。仅供科学研究使用，不适用于临床诊断或其他用途。
  • Uniprot No.：
    Q6UXN8
  • 基因名：
    CLEC9A
  • 别名：
    C type lectin domain family 9; member A antibody; C-type lectin domain family 9 member A antibody; CLC9A_HUMAN antibody; CLEC9A antibody; DNGR1 antibody; HEEE9341 antibody; PRO34046 antibody; UNQ9341 antibody
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human CLEC9A protein
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Monoclonal
  • 抗体亚型：
    hIgG4(S228P)
  • 纯化方式：
    Affinity-chromatography
  • 克隆号：
    9H7
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:5000-1:50000
  • Protocols：
    ELISA Protocol
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

产品评价

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CLEC9A antibodies

CLEC9A Proteins

CLEC9A ELISA kits

靶点详情

  • 功能：
    Functions as an endocytic receptor on a small subset of myeloid cells specialized for the uptake and processing of material from dead cells. Recognizes filamentous form of actin in association with particular actin-binding domains of cytoskeletal proteins, including spectrin, exposed when cell membranes are damaged, and mediate the cross-presentation of dead-cell associated antigens in a Syk-dependent manner.
  • 基因功能参考文献：
    1. Clec9a is responsible for the antigen cross-presentation of dendritic cell subsets and may be a target of immunotherapy PMID: 27250027
    2. findings demonstrate that CLEC9A is a specialized receptor that modulates the innate immune response when there is a mycobacterial infection PMID: 29065139
    3. Data indicate that blood dendritic cell antigen 3 BDCA3(+) and C-type lectin domain family 9, member A CLEC9A(+) dendritic cells (DC) are of major importance in the induction of anti-viral and anti-tumor immunity. PMID: 24910448
    4. Activated dendritic cell subsets expressing CD141/CLEA9A/CD1c, likely recruited into the tubulointerstitium, are positioned to play a role in the development of fibrosis and, thus, progression to chronic kidney disease. PMID: 24049150
    5. study showsn that the DNGR-1 ligand is preserved from yeast to man and corresponds to the F-actin component of the cellular cytoskeleton; identification of F-actin as a DNGR-1 ligand suggests that cytoskeletal exposure is a universal sign of cell damage that can be targeted by the innate immune system to initiate immunity PMID: 22483800
    6. High expression of DNGR-1 specifically and universally identifies a unique dendritic cells subset in mouse and humans. PMID: 22442345
    7. propose that Clec9A provides targeted recruitment of the adaptive immune system during infection and can also be utilized to enhance immune responses generated by vaccines. PMID: 22483802
    8. Data show that CLEC9A is only expressed on immature BDCA3(+) myeloid dendritic cells (mDCs). PMID: 22234694
    9. For production of cytotoxic T cells, transgenic DEC-205 and Clec9A, but not Clec12A, are effective targets for antibody-mediated delivery of antigens for vaccination, although only in the presence of adjuvants. PMID: 21677141
    10. A population of human dendritic cells (DC) that expresses DNGR-1 (CLEC9A) and high levels of BDCA3 and resembles mouse CD8alpha+ DCs in phenotype and function, is characterized. PMID: 20479117
    11. DC, NK lectin group receptor-1 (DNGR-1) is a C-type lectin of the NK cell receptor group PMID: 18497879
    12. CLEC9A functions as an activation receptor PMID: 18408006
    13. analysis of differences between mouse and human Clec9A PMID: 18669894
    14. CLEC9A functions as a SYK-coupled C-type lectin receptor to mediate sensing of necrosis by the principal dendritic-cell subset involved in regulating cross-priming to cell-associated antigens PMID: 19219027
    15. The paper cited (J Clin Invest. 2008 Jun;118(6):2098-110) is the first characterization of human and mouse CLEC9A (a.k.a DNGR-1) PMID: 18497879

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  • 亚细胞定位：
    Membrane; Single-pass type II membrane protein.
  • 组织特异性：
    In peripheral blood highly restricted on the surface of BDCA31(+) dendritic cells and on a small subset of CD14(+) and CD16(-) monocytes.
  • 数据库链接：

    HGNC: 26705

    OMIM: 612252

    KEGG: hsa:283420

    STRING: 9606.ENSP00000348074

    UniGene: Hs.531189

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