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  4. CDH6 Recombinant Monoclonal Antibody

CDH6 Recombinant Monoclonal Antibody

说明书
  • 中文名称：
    CDH6重组抗体
  • 货号：
    CSB-RA005055MA1HU
  • 规格：
    ￥1320
  • 图片：
    • The Binding Activity of Human CDH6 with Anti-CDH6 Recombinant Antibody
      Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CDH6 (CSB-MP005055HU1) at 2 μg/mL can bind Anti-CDH6 recombinant antibody. The EC50 is 2.421-2.802 ng/mL.
    • The Binding Activity of Mouse CDH6 with Anti-CDH6 Recombinant Antibody
      Activity: Measured by its binding ability in a functional ELISA. Immobilized Mouse CDH6 (CSB-MP005055MO1) at 2 μg/mL can bind Anti-CDH6 recombinant antibody. The EC50 is 1.884-2.164 ng/mL.
    • The Binding Activity of Rat CDH6 with Anti-CDH6 Recombinant Antibody
      Activity: Measured by its binding ability in a functional ELISA. Immobilized Rat CDH6 (CSB-MP005055RA1) at 2 μg/mL can bind Anti-CDH6 recombinant antibody. The EC50 is 1.630-1.837 ng/mL.
  • 其他：

产品详情

  • 产品描述：
    CDH6重组单克隆抗体（CSB-RA005055MA1HU）是针对钙黏蛋白家族成员CDH6开发的高特异性科研工具。CDH6是一种跨膜糖蛋白，主要参与细胞间黏附及信号转导调控，在胚胎发育、器官形成及部分肿瘤微环境重塑中发挥重要作用。本抗体采用重组技术制备，具有优异的批次稳定性，经ELISA方法严格验证，可实现对CDH6蛋白的特异性识别，适用于体外样本中靶标蛋白的定量检测与分析。在科研领域，该产品可应用于肿瘤生物学研究中CDH6表达模式的探索，例如在肾癌、卵巢癌等模型中的功能机制研究；同时支持细胞黏附实验、迁移侵袭实验等体外研究，为解析CDH6在组织稳态维持及病理状态下的调控网络提供可靠工具。该抗体还可与其他分子生物学技术联用，助力于疾病相关信号通路的分子机制解析。
  • Uniprot No.：
    P55285
  • 基因名：
    CDH6
  • 别名：
    CDH6 Recombinant Monoclonal Antibody
  • 反应种属：
    Human, Macaca fascicularis, Rat
  • 免疫原：
    Recombinant Human CDH6 protein
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Monoclonal
  • 抗体亚型：
    hIgG1
  • 纯化方式：
    Affinity-chromatography
  • 克隆号：
    8B4
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
    ELISA Protocol
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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CDH6 antibodies

CDH6 Proteins

靶点详情

  • 功能：
    Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
  • 基因功能参考文献：
    1. Tumor suppressor genes deleted in liver cancer 1 (DLC1), F-box/WD-repeat-containing protein 7 (FBXW7), and cadherin-6 (CDH6) were identified as presumed targets in Cholangiocarcinoma (CC).Inverse correlation between promoter methylation and expression suggested miR-129-2 and members of the miR-200 family (miR-200a, miR-200b, and miR-429) as novel tumor suppressors and oncomiRs, respectively, in CC PMID: 27593557
    2. The chromatin modifications were determined at five PRC2 targets commonly underexpressed in multiple myeloma (CIITA, CXCL12, GATA2, CDH6 and ICSBP/IRF8). The selected genes were confirmed to be underexpressed in MM compared to normal plasma cells. PMID: 20634887
  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 组织特异性：
    Highly expressed in brain, cerebellum, and kidney. Lung, pancreas, and gastric mucosa show a weak expression. Also expressed in certain liver and kidney carcinomas.
  • 数据库链接：

    HGNC: 1765

    OMIM: 603007

    KEGG: hsa:1004

    STRING: 9606.ENSP00000265071

    UniGene: Hs.124776

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