CD37 Recombinant Monoclonal Antibody

中文名称：

CD37重组抗体
货号：

CSB-RA004928MA1HU
规格：

￥1320
图片：
IHC image of CSB-RA004928MA1HU diluted at 1:200 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-human polymer IgG labeled by HRP and visualized using 0.05% DAB.
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CSB-RA004928MA1HU CD37重组单克隆抗体是针对人源CD37抗原设计的高特异性科研工具。CD37作为四次跨膜蛋白家族成员，在B淋巴细胞表面特异性表达，参与调控细胞黏附、迁移及信号转导，其异常表达与B细胞淋巴瘤等疾病密切相关。本抗体经ELISA及免疫组化（IHC）双重平台验证，在IHC应用中可清晰显示石蜡包埋组织中B淋巴细胞的膜定位特征，推荐使用稀释度为1:50-1:200，能有效区分目标蛋白的组织分布差异。ELISA检测体系显示其具备出色的线性反应范围，适用于体外样本的定量分析。该产品可为B细胞发育分化研究、淋巴瘤微环境分析、免疫细胞表面标记物检测等实验提供可靠支持，尤其在探究B细胞相关疾病的分子机制、筛选潜在治疗靶点及开发体外检测方法等领域具有重要应用价值。通过严格的抗原亲和纯化工艺，确保批次间稳定性，适用于需要高重复性的长期研究项目。
Uniprot No.：

P11049
基因名：

CD37
别名：

CD37 Recombinant Monoclonal Antibody
反应种属：

Human
免疫原：

Recombinant Human CD37 protein
免疫原种属：

Homo sapiens (Human)
标记方式：

Non-conjugated
克隆类型：

Monoclonal
抗体亚型：

hIgG1
纯化方式：

Affinity-chromatography
克隆号：

9H6
浓度：

It differs from different batches. Please contact us to confirm it.
保存缓冲液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
产品提供形式：

Liquid
应用范围：

ELISA, IHC
推荐稀释比：

Application Recommended Dilution

IHC 1:50-1:200
Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
储存条件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
货期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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基因功能参考文献：
1. CD37 is a critical determinant of rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone outcome in diffuse large B-cell lymphoma. PMID: 27760757
2. Data indicate that cell differentiation antigen 37 (CD37) is well expressed and a potential drug target in acute myeloid leukemia (AML). PMID: 25934707
3. The CD37-targeted antibody-drug conjugate IMGN529 is highly active against human CLL and in a novel CD37 transgenic murine leukemia model. PMID: 24445867
4. Data indicate that enhanced antibody-dependent cell cytotoxicity (ADCC) is observed against chronic lymphocytic leukemia cells and is sustained at concentrations of SMIP-016(GV) as low at 5E(-6) microg/mL on cells expressing minimal CD37 antigen. PMID: 23883821
5. Identify two tyrosine residues in tetraspanin CD37 directly mediating transduction of survival and apoptotic signals. PMID: 22624718
6. In the absence of both CD37 and Tssc6, immune function is further altered when compared with CD37- or Tssc6-deficient transgenic mice, demonstrating a complementary role for these two molecules in cellular immunity. PMID: 20709950
7. CD37 cross-linking on human T cells transduces signals that lead to complete inhibition of CD3-induced T cell proliferation. PMID: 14978098
8. CD37 is important for dectin-1 stabilization in APC membranes and controls dectin-1-mediated IL-6 production. PMID: 17182550
9. provide strong justification for CD37 as a therapeutic target and introduce small modular immunopharmaceuticals as a novel class of targeted therapies for B-cell malignancies PMID: 17440052
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亚细胞定位：

Membrane; Multi-pass membrane protein.
蛋白家族：

Tetraspanin (TM4SF) family
组织特异性：

B-lymphocytes.
数据库链接：

HGNC: 1666

OMIM: 151523

KEGG: hsa:951

STRING: 9606.ENSP00000325708

UniGene: Hs.166556

CD37 Recombinant Monoclonal Antibody

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