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  4. CARS Recombinant Monoclonal Antibody

CARS Recombinant Monoclonal Antibody

说明书
  • 中文名称：
    CARS重组抗体
  • 货号：
    CSB-RA158403A0HU
  • 规格：
    ￥1320
  • 图片：
    • Western Blot
      Positive WB detected in: Hela whole cell lysate, A549 whole cell lysate, Jurkat whole cell lysate
      All lanes: CARS antibody at 1:500
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 86, 83, 95 kDa
      Observed band size: 95 kDa
  • 其他：

产品详情

  • 产品描述：
    CARS Recombinant Monoclonal Antibody（CSB-RA158403A0HU）是针对人源CARS蛋白研发的高特异性重组单克隆抗体，适用于ELISA和Western Blot（WB）等免疫检测实验。CARS（Cysteinyl-tRNA Synthetase）是细胞质氨基酰-tRNA合成酶家族成员，负责催化半胱氨酸与其对应tRNA的结合，在蛋白质翻译过程中发挥关键作用，并与氧化应激调控、细胞代谢等生物学过程密切相关。本抗体经严格验证，在WB实验中可特异性识别天然状态下的人源CARS蛋白，推荐使用稀释比例为1:500至1:2000，实验结果显示清晰的单一目标条带，且不同批次间稳定性优异，能够有效检测多种哺乳动物细胞或组织样本中的内源性CARS表达。该产品适用于探索CARS在蛋白质合成调控、氧化应激反应及代谢相关疾病机制中的功能研究，可广泛应用于基因表达分析、信号通路研究及分子互作实验等基础科研领域，为研究者在细胞生物学、分子病理学等方向提供可靠的工具支持。
  • Uniprot No.：
    P49589
  • 基因名：
    CARS
  • 别名：
    Cysteine--tRNA ligase, cytoplasmic (EC 6.1.1.16) (Cysteinyl-tRNA synthetase) (CysRS), CARS
  • 反应种属：
    Human
  • 免疫原：
    A synthesized peptide derived from human CARS
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Monoclonal
  • 抗体亚型：
    Rabbit IgG
  • 纯化方式：
    Affinity-chromatography
  • 克隆号：
    8B11
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
  • Protocols：
    ELISA Protocol
    Western Blotting (WB) Protocol
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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CARS antibodies

CARS Proteins

靶点详情

  • 功能：
    Catalyzes the ATP-dependent ligation of cysteine to tRNA(Cys).
  • 基因功能参考文献：
    1. Four single nucleotide polymorphisms (SNPs) of CARS were significantly associated with gastric cancer risk in both the discovery stage and the validation stage PMID: 28409418
    2. The risk (G and C) and non-risk (C and T) allele frequencies of the SNPs at the rs1888747 and rs739401 loci of FRMD3 and CARS, respectively, did not differ significantly between the diabetics with (case) and without (control) nephropathy (P > 0.05). PMID: 26909942
    3. Loss of CARS, the cysteinyl-tRNA synthetase, suppresses ferroptosis induced by erastin, which inhibits the cystine-glutamate antiporter known as system xc(-). PMID: 26184909
    4. CARS is a novel fusion partner of anaplastic lymphoma kinase in anaplastic large-cell lymphoma and inflammatory myofibroblastic tumor cases. PMID: 12112524
    5. Specificity of anticodon recognition by human CysRS is higher than that of its bacterial counterparts. PMID: 17303165

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  • 相关疾病：
    A chromosomal aberration involving CARS is associated with inflammatory myofibroblastic tumors (IMTs). Translocation t(2;11)(p23;p15) with ALK.
  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Class-I aminoacyl-tRNA synthetase family
  • 数据库链接：

    HGNC: 1493

    OMIM: 123859

    KEGG: hsa:833

    STRING: 9606.ENSP00000369897

    UniGene: Hs.274873

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