C1S Recombinant Monoclonal Antibody

中文名称：

C1S重组抗体
货号：

CSB-RA003657MA1HU
规格：

￥1320
图片：
IHC image of CSB-RA003657MA1HU diluted at 1:100 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-Human IgG labeled by HRP and visualized using 0.05% DAB.
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CSB-RA003657MA1HU C1S重组单克隆抗体是针对补体系统关键成分C1酯酶亚基（C1S）开发的高特异性检测工具。该抗体靶向的C1S蛋白作为经典补体激活途径C1复合物的核心蛋白酶，在机体免疫防御及炎症调控中发挥重要作用，其异常表达与多种免疫相关病理过程密切相关。本产品经ELISA和免疫组化（IHC）双平台严格验证，在石蜡包埋组织切片中表现出优异抗原识别能力，推荐使用1:50-1:200稀释度可获得清晰特异性染色。通过重组表达系统生产及多级亲和纯化工艺，确保抗体批次间高度一致性，为补体通路调控机制、自身免疫性疾病模型建立及感染免疫应答研究提供可靠实验支持，尤其适用于心血管、肾脏等器官的局部补体激活现象检测。该试剂严格限定于体外科学研究领域，不涉及任何临床相关用途。
Uniprot No.：

P09871
基因名：

C1S
别名：

C1S Recombinant Monoclonal Antibody
反应种属：

Human
免疫原：

Recombinant Human C1S protein
免疫原种属：

Homo sapiens (Human)
标记方式：

Non-conjugated
克隆类型：

Monoclonal
抗体亚型：

hIgG1
纯化方式：

Affinity-chromatography
克隆号：

12F12
浓度：

It differs from different batches. Please contact us to confirm it.
保存缓冲液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
产品提供形式：

Liquid
应用范围：

ELISA, IHC
推荐稀释比：

Application Recommended Dilution

IHC 1:50-1:200
Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
储存条件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
货期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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功能：

C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4.
基因功能参考文献：
1. TNT003, an inhibitor of the serine protease C1s, prevents complement activation induced by cold agglutinins. PMID: 24695853
2. Data indicate that complement C1s mRNA level was low in ICR-derived glomerulonephritis (ICGN) mice liver as compared with age-matched ICR mice. PMID: 23989031
3. A molecular switch governs the interaction between the human complement protease C1s and its substrate, complement C4. PMID: 23592783
4. Four positively charged amino acids on the serine protease domain appear to form a catalytic exosite that is required for efficient cleavage of C4 in the classical pathway of complement. PMID: 22855709
5. Detailed mapping of post-translational modifications and insights into the C1r/C1s binding sites. PMID: 20008834
6. Interaction with the prime side residues at the cleavage point in C1s enhances the affinity of the enzyme for complement 2 and complement 4 substrates; these prime subsite residues mediate positive cooperativity in the cleavage of the substrate. PMID: 14674770
7. full specificity of the enzyme using a randomized phage display library PMID: 16169853
8. There are splice variants of C1s mRNA transcripts in normal human cells PMID: 18062908
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相关疾病：

Complement component C1s deficiency (C1SD); Ehlers-Danlos syndrome, periodontal type, 2 (EDSPD2)
蛋白家族：

Peptidase S1 family
数据库链接：

HGNC: 1247

OMIM: 120580

KEGG: hsa:716

STRING: 9606.ENSP00000328173

UniGene: Hs.458355

C1S Recombinant Monoclonal Antibody

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