ptxA Antibody, Biotin conjugated

^{Rare Species}

产品详情

产品名称：

Rabbit anti-Bordetella pertussis ptxA Polyclonal antibody
Uniprot No.：

P04977
基因名：

ptxA
别名：

ptxA antibody; BP3783 antibody; Pertussis toxin subunit 1 antibody; PTX S1 antibody; Islet-activating protein S1 antibody; IAP S1 antibody; NAD-dependent ADP-ribosyltransferase antibody; EC 2.4.2.- antibody
宿主：

Rabbit
反应种属：

Bordetella pertussis
免疫原：

Recombinant Bordetella pertussis Pertussis toxin subunit 1 protein (35-269AA)
免疫原种属：

Bordetella pertussis
标记方式：

Biotin
克隆类型：

Polyclonal
抗体亚型：

IgG
纯化方式：

>95%, Protein G purified
浓度：

It differs from different batches. Please contact us to confirm it.
保存缓冲液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
产品提供形式：

Liquid
应用范围：

ELISA
Protocols：

ELISA Protocol
储存条件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
货期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

S1 is an NAD-dependent ADP-ribosyltransferase, which plays a crucial role in the pathogenesis of B.pertussis causing disruption of normal host cellular regulation. It catalyzes the ADP-ribosylation of a cysteine in the alpha subunit of host heterotrimeric G proteins. In the absence of G proteins it also catalyzes the cleavage of NAD(+) into ADP-ribose and nicotinamide. It irreversibly uncouples the G-alpha GTP-binding proteins from their membrane receptors.
基因功能参考文献：
1. It has been proposed that it is the systemic activity of pertussis toxin and not pulmonary pathology that promotes mortality in critical pertussis. PMID: 28784932
亚细胞定位：

Secreted. Note=The individual chains are secreted by a sec-dependent mechanism into the periplasm. Then, S1 associates with the outer membrane before it joins with the B subunit to form the secretion-competent holotoxin. The type IV secretion system ptl mediates secretion of assembled toxin through the outer membrane.
蛋白家族：

Bacterial exotoxin subunit A family
数据库链接：

KEGG: bpe:BP3783

STRING: 257313.BP3783