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中文名称:lexA兔多克隆抗体, FITC偶联
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货号:CSB-PA363985HC01ENV
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规格:¥880
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其他:
产品详情
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产品名称:Rabbit anti-Escherichia coli lexA Polyclonal antibody
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Uniprot No.:
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基因名:lexA
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别名:lexA antibody; exrA antibody; spr antibody; tsl antibody; umuA antibody; b4043 antibody; JW4003LexA repressor antibody; EC 3.4.21.88 antibody
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宿主:Rabbit
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反应种属:Escherichia coli
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免疫原:Recombinant Escherichia coli LexA repressor protein (1-202AA)
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免疫原种属:Escherichia coli
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标记方式:FITC
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克隆类型:Polyclonal
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抗体亚型:IgG
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纯化方式:>95%, Protein G purified
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浓度:It differs from different batches. Please contact us to confirm it.
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保存缓冲液:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
产品提供形式:Liquid
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储存条件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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货期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途:For Research Use Only. Not for use in diagnostic or therapeutic procedures.
相关产品
靶点详情
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功能:Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. Implicated in hydroxy radical-mediated cell death induced by hydroxyurea treatment.The SOS response controls an apoptotic-like death (ALD) induced (in the absence of the mazE-mazF toxin-antitoxin module) in response to DNA damaging agents that is mediated by RecA and LexA.
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基因功能参考文献:
- The conformational flexibility of unbound LexA is the key element in establishing a co-ordinated SOS response. PMID: 21576225
- LexA regulated genes exhibit phenotypic heterogeneity as high level expression is observed in only a small subpopulation. PMID: 21070632
- NMR analysis of LexA catalytic domain in its active conformation PMID: 15929009
- oligomerization of LexA is proposed to be a possible regulation mechanism of the Escherichia coli SOS regulon in response to environmental conditions resulting in acidic intracellular pH. Structural changes on LexA repressor promoted by acidic pH. PMID: 16701697
- LexA binds to and represses the promoter of antC of coliphage N15. PMID: 17586637
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蛋白家族:Peptidase S24 family
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数据库链接:
KEGG: ecj:JW4003
STRING: 316385.ECDH10B_4232
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