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  4. ZNF366 Antibody, Biotin conjugated

ZNF366 Antibody, Biotin conjugated

说明书
  • 中文名称：
    ZNF366兔多克隆抗体, Biotin偶联
  • 货号：
    CSB-PA026702LD01HU
  • 规格：
    ￥880
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ZNF366 Polyclonal antibody
  • Uniprot No.：
    Q8N895
  • 基因名：
    ZNF366
  • 别名：
    ZNF366 antibody; Zinc finger protein 366 antibody; Dendritic cell-specific transcript protein antibody; DC-SCRIPT antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Zinc finger protein 366 protein (455-650AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Biotin
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
    ELISA Protocol
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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ZNF366 antibodies

ZNF366 Proteins

靶点详情

  • 功能：
    Has transcriptional repression activity. Acts as corepressor of ESR1; the function seems to involve CTBP1 and histone deacetylases.
  • 基因功能参考文献：
    1. These data demonstrate that besides nuclear receptor regulation, DC-SCRIPT also modulates activation of NF-kappaBp65 after TLR activation in human DCs. PMID: 26170389
    2. these data show that DC-SCRIPT acts as a novel regulator of CDKN2B and induces cell cycle arrest in ESR1-positive breast cancer cells. PMID: 25663546
    3. DC-SCRIPT serves an important role in regulating GR function in DCs, corepressing GR-dependent upregulation of the tolerance-inducing transcription factor GILZ. PMID: 23440419
    4. DC-SCRIPT is a key regulator of androgen receptor and vitamin d receptor that play an opposite role in prostate cancer etiology and loss of DC-SCRIPT may be involved in the onset of prostate cancer. PMID: 22473304
    5. DC-SCRIPT has a primary role in the regulation of interleukin (IL)-10 production by monocytes. PMID: 22615205
    6. study provides a higher level of evidence that DC-SCRIPT is indeed an independent, pure prognostic, factor for primary breast cancer and shows that DC-SCRIPT mRNA expression is most informative for either ESR1-positive and/or ESR2-low pT1 tumors PMID: 21122099
    7. DC-SCRIPT can act as a tumor suppressor in breast cancer development.[review] PMID: 20478364
    8. DC-SCRIPT consists of a proline-rich region, 11 C2H2-type zinc fingers, and an acidic region. Localization studies reveal that DC-SCRIPT resides in the nucleus and that nuclear localization is critically dependent on the zinc fingers. (DC-SCRIPT) PMID: 16393996
    9. Results indicate that ZNF366 may play an important role in regulating the expression of genes in response to estrogen. PMID: 17085477
    10. Identification of ZNF366 and PTPRD as novel determinants of plasma homocysteine in a family-based genome-wide association study PMID: 19525478

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Expressed in immature and mature dendritic cells (DCs). Not detected in other blood cell types.
  • 数据库链接：

    HGNC: 18316

    OMIM: 610159

    KEGG: hsa:167465

    STRING: 9606.ENSP00000313158

    UniGene: Hs.224794

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