ZIC5 Antibody

中文名称：

ZIC5兔多克隆抗体
货号：

CSB-PA850433LA01HU
规格：

￥440
图片：
IHC image of CSB-PA850433LA01HU diluted at 1:200 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
其他：

产品详情

产品名称：

Rabbit anti-Homo sapiens (Human) ZIC5 Polyclonal antibody
Uniprot No.：

Q96T25
基因名：

ZIC5
别名：

zic5 antibody; ZIC5_HUMAN antibody; Zinc finger protein of the cerebellum 5 antibody; Zinc finger protein ZIC 5 antibody
宿主：

Rabbit
反应种属：

Human
免疫原：

Recombinant Human Zinc finger protein ZIC 5 protein (217-276AA)
免疫原种属：

Homo sapiens (Human)

标记方式：

Non-conjugated

本页面中的产品，ZIC5 Antibody (CSB-PA850433LA01HU)，的标记方式是Non-conjugated。对于ZIC5 Antibody，我们还提供其他标记。见下表：

标记方式	货号	产品名称	应用
HRP	CSB-PA850433LB01HU	ZIC5 Antibody, HRP conjugated	ELISA
FITC	CSB-PA850433LC01HU	ZIC5 Antibody, FITC conjugated
Biotin	CSB-PA850433LD01HU	ZIC5 Antibody, Biotin conjugated	ELISA

克隆类型：

Polyclonal
抗体亚型：

IgG
纯化方式：

>95%, Protein G purified
浓度：

It differs from different batches. Please contact us to confirm it.
保存缓冲液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
产品提供形式：

Liquid
应用范围：

ELISA, IHC
推荐稀释比：

Application Recommended Dilution

IHC 1:200-1:500
Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
储存条件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
货期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Essential for neural crest development, converting cells from an epidermal fate to a neural crest cell fate. Binds to DNA.
基因功能参考文献：
1. hsa_circ_0007534 serves as an oncogene in glioma via promoting ZIC5 expression by repressing miR-761 availability. PMID: 29605301
2. ZIC5 positively regulated the proliferation, migration, and survival of prostate colorectal cancer cells PMID: 29024195
3. ZIC5 is highly upregulated in non-small cell lung cancer tumor tissues and may act as an oncogene by influencing CCNB1 and CDK1 complex expression PMID: 27663664
4. ZIC1, ZIC2, and ZIC5 may have roles in meningiomas PMID: 20199689
5. the smallest 13q deletion associated to DWM allows further narrowing of the previously established critical region for this brain malformation to 13q32.2-32.3. Among the few genes of the deleted region, ZIC2 and ZIC5 seem the most plausible candidates. PMID: 20683983
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亚细胞定位：

Nucleus.
蛋白家族：

GLI C2H2-type zinc-finger protein family
数据库链接：

HGNC: 20322

OMIM: 617896

KEGG: hsa:85416

STRING: 9606.ENSP00000267294

UniGene: Hs.508570