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  4. ZBED1 Antibody, Biotin conjugated

ZBED1 Antibody, Biotin conjugated

说明书
  • 中文名称：
    ZBED1兔多克隆抗体, Biotin偶联
  • 货号：
    CSB-PA02715D0Rb
  • 规格：
    ￥880
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ZBED1 Polyclonal antibody
  • Uniprot No.：
    O96006
  • 基因名：
    ZBED1
  • 别名：
    Ac like transposable element antibody; ALTE antibody; BED type zinc finger domain containing protein 1 antibody; DNA replication related element binding factor antibody; dREF homolog antibody; hDREF antibody; KIAA0785 antibody; Putative Ac like transposon antibody; Putative Ac-like transposable element antibody; TRAMP antibody; ZBED1 antibody; ZBED1_HUMAN antibody; Zinc finger BED domain-containing protein 1 antibody; Zinc finger BED type containing 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Zinc finger BED domain-containing protein 1 protein (1-210AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Biotin
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
    ELISA Protocol
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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ZBED1 antibodies

ZBED1 Proteins

靶点详情

  • 功能：
    Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase which sumoylates CHD3/Mi2-alpha, causing its release from DNA. This results in suppression of CHD3/Mi2-alpha transcription repression, increased recruitment of RNA polymerase II to gene promoters and positive regulation of transcription including H1-5 and ribosomal proteins such as: RPS6, RPL10A, and RPL12. The resulting increased transcriptional activity drives cell proliferation. Binds to 5'-TGTCG[CT]GA[CT]A-3' consensus sequences in gene promoters of ribosomal proteins.; (Microbial infection) Binds to human adenovirus gene promoters and contributes to transcriptional repression and virus growth inhibition during early stages of infection.
  • 基因功能参考文献：
    1. These findings identify DREF as a novel adenovirus E1A C terminus binding partner and provide evidence supporting a role for DREF in viral replication. PMID: 25210186
    2. expression of hDREF/KIAA0785 may have a role in regulation of human genes related to cell proliferation PMID: 12663651
    3. self-association of hDREF via the hATC domain is necessary for its nuclear accumulation and DNA binding. PMID: 17209048
    4. hDREF is an important transcription factor for cell proliferation which plays roles in cell cycle-dependent regulation of a number of ribosomal protein genes PMID: 17220279
  • 亚细胞定位：
    Nucleus, PML body. Nucleus.; Nucleus, PML body.
  • 组织特异性：
    Ubiquitously expressed at low levels. Expression is highest in skeletal muscle, heart, spleen and placenta.
  • 数据库链接：

    HGNC: 447

    OMIM: 300178

    KEGG: hsa:9189

    STRING: 9606.ENSP00000370616

    UniGene: Hs.131452

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