WDR91 Antibody, FITC conjugated

产品详情

产品名称：

Rabbit anti-Homo sapiens (Human) WDR91 Polyclonal antibody
Uniprot No.：

A4D1P6
基因名：

WDR91
别名：

HSPC049 antibody; WD repeat containing protein 91 antibody; WD repeat domain 91 antibody; WD repeat-containing protein 91 antibody; WDR 91 antibody; WDR91 antibody; WDR91_HUMAN antibody
宿主：

Rabbit
反应种属：

Human
免疫原：

Recombinant Human WD repeat-containing protein 91 protein (1-747AA)
免疫原种属：

Homo sapiens (Human)
标记方式：

FITC
克隆类型：

Polyclonal
抗体亚型：

IgG
纯化方式：

>95%, Protein G purified
浓度：

It differs from different batches. Please contact us to confirm it.
保存缓冲液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
产品提供形式：

Liquid
储存条件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
货期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport. It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome. May play a role in meiosis.
基因功能参考文献：
1. suggest a role for the WDR81-WDR91 complex in the fusion of endolysosomal compartments and the absence of WDR81 leads to impaired receptor trafficking and degradation PMID: 27126989
2. WDR91 serves as a Rab7 effector that is essential for neuronal development by facilitating endosome conversion in the endosome-lysosome pathway. PMID: 28860274
亚细胞定位：

Early endosome membrane; Peripheral membrane protein. Late endosome membrane.
蛋白家族：

WD repeat WDR91 family
数据库链接：

HGNC: 24997

KEGG: hsa:29062

STRING: 9606.ENSP00000346466

UniGene: Hs.459858