WDR74 Antibody, HRP conjugated

产品详情

产品名称：

Rabbit anti-Homo sapiens (Human) WDR74 Polyclonal antibody
Uniprot No.：

Q6RFH5
基因名：

WDR74
别名：

WDR74 antibody; NSA1 antibody; WD repeat-containing protein 74 antibody; NOP seven-associated protein 1 antibody
宿主：

Rabbit
反应种属：

Human
免疫原：

Recombinant Human WD repeat-containing protein 74 protein (111-366AA)
免疫原种属：

Homo sapiens (Human)
标记方式：

HRP
克隆类型：

Polyclonal
抗体亚型：

IgG
纯化方式：

Antigen Affinity Purified
浓度：

It differs from different batches. Please contact us to confirm it.
保存缓冲液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
产品提供形式：

Liquid
应用范围：

ELISA
Protocols：

ELISA Protocol
储存条件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
货期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Regulatory protein of the MTREX-exosome complex involved in the synthesis of the 60S ribosomal subunit. Participates in an early cleavage of the pre-rRNA processing pathway in cooperation with NVL. Required for blastocyst formation, is necessary for RNA transcription, processing and/or stability during preimplantation development.
基因功能参考文献：
1. knockdown of WDR74 leads to significant defects in the pre-rRNA cleavage within the internal transcribed spacer 1, occurring in an early stage of the processing pathway. When the dissociation of WDR74 from the MTR4-containing exonuclease complex was impaired upon expression of mutant NVL2, the same processing defect, with partial migration of WDR74 from the nucleolus towards the nucleoplasm, was observed. PMID: 29107693
2. results suggest that WDR74 is a novel regulatory protein of the MTR4-exsosome complex whose interaction is regulated by NVL2 and is involved in ribosome biogenesis PMID: 26456651
亚细胞定位：

Nucleus, nucleolus. Nucleus.
数据库链接：

HGNC: 25529

OMIM: 617947

KEGG: hsa:54663

STRING: 9606.ENSP00000278856

UniGene: Hs.654620