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  4. WDR73 Antibody, Biotin conjugated

WDR73 Antibody, Biotin conjugated

说明书
  • 中文名称：
    WDR73兔多克隆抗体, Biotin偶联
  • 货号：
    CSB-PA744047LD01HU
  • 规格：
    ￥880
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) WDR73 Polyclonal antibody
  • Uniprot No.：
    Q6P4I2
  • 基因名：
    WDR73
  • 别名：
    WDR73 antibody; HSPC264WD repeat-containing protein 73 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human WD repeat-containing protein 73 protein (163-366AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Biotin
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
    ELISA Protocol
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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WDR73 antibodies

WDR73 Proteins

靶点详情

  • 功能：
    May play a role in the regulation of microtubule organization and dynamics.
  • 基因功能参考文献：
    1. We expanded the clinical phenotype of GMS with WDR73 gene defect to include retinal dysfunction with missense mutation and developmental dysplasia of the hip. PMID: 29929488
    2. WDR73 as a candidate gene of severe intellectual disability and cerebellar hypoplasia. PMID: 27983999
    3. We document postnatal onset of CA, a retinopathy, basal ganglia degeneration, and short stature as novel features of WDR73-related disease, and define WDR73-related disease as a new entity of infantile neurodegeneration. PMID: 26123727
    4. Nonsense mutation in the WDR73 gene is associated with Galloway-Mowat syndrome PMID: 25873735
    5. WDR73 interacts with mitotic microtubules to regulate cell cycle progression, proliferation and survival in brain PMID: 26070982
    6. WDR73 plays a crucial role in the maintenance of cell architecture and cell survival. PMID: 25466283

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  • 相关疾病：
    Galloway-Mowat syndrome 1 (GAMOS1)
  • 亚细胞定位：
    Cytoplasm, cytosol. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Cleavage furrow.
  • 蛋白家族：
    WD repeat WDR73 family
  • 组织特异性：
    Expressed in kidney and brain. In the kidney, expressed in glomeruli, most probably in podocytes, and in tubules (at protein level). In the brain, expressed in the cerebellum, with high levels in Purkinje cells and their projecting axons, in the deep cere
  • 数据库链接：

    HGNC: 25928

    OMIM: 251300

    KEGG: hsa:84942

    STRING: 9606.ENSP00000387982

    UniGene: Hs.745027

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