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  4. UXS1 Antibody

UXS1 Antibody

说明书
  • 中文名称：
    UXS1兔多克隆抗体
  • 货号：
    CSB-PA822754LA01HU
  • 规格：
    ￥440
  • 图片：
    • Western Blot
      Positive WB detected in: JK whole cell lysate(20µg), HepG2 whole cell lysate(20µg), PC-3 whole cell lysate(20µg), A375 whole cell lysate(20µg)
      All lanes: UXS1 antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/20000 dilution
      Predicted band size: 48,49,29 kDa
      Observed band size: 70-100 kDa
      Exposure time: 120s
    • IHC image of CSB-PA822754LA01HU diluted at 1:50 and staining in paraffin-embedded human Lung tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB. Secondary antibody only control: uses 1% BSA instead of primary antibody
    • IHC image of CSB-PA822754LA01HU diluted at 1:50 and staining in paraffin-embedded human Stomach tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB. Secondary antibody only control: uses 1% BSA instead of primary antibody
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) UXS1 Polyclonal antibody
  • Uniprot No.：
    Q8NBZ7
  • 基因名：
    UXS1
  • 别名：
    UXS1 antibody; UNQ2538/PRO6079 antibody; UDP-glucuronic acid decarboxylase 1 antibody; EC 4.1.1.35 antibody; UDP-glucuronate decarboxylase 1 antibody; UGD antibody; UXS-1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human UDP-glucuronic acid decarboxylase 1 protein (201-420AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，UXS1 Antibody (CSB-PA822754LA01HU)，的标记方式是Non-conjugated。对于UXS1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA822754LB01HU UXS1 Antibody, HRP conjugated ELISA
    FITC CSB-PA822754LC01HU UXS1 Antibody, FITC conjugated
    Biotin CSB-PA822754LD01HU UXS1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:1:50-1:200
  • Protocols：
    ELISA Protocol
    Western Blotting (WB) Protocol
    Immunohistochemistry (IHC) Protocol
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

产品评价

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UXS1 antibodies

UXS1 Proteins

靶点详情

  • 功能：
    Catalyzes the NAD-dependent decarboxylation of UDP-glucuronic acid to UDP-xylose. Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis.
  • 基因功能参考文献：
    1. The persistence of a latent hexamer-building interface in the human enzyme suggests that the ancestral UXS may have been a hexamer. PMID: 25521717
    2. hUXS forms a tetramer in solution that is important for activity. The higher activity of the tetramer coupled with the relative instability of the dimeric complex suggests that an association-dissociation mechanism may regulate hUXS activity. PMID: 23656592
    3. UDP-glucuronate decarboxylase, a key enzyme in proteoglycan synthesis: cloning, characterization, and localization. PMID: 11877387
    4. Complementation was achieved by expression of a cytoplasmic variant of UDP-xylose Synthase, which proves the existence of a functional Golgi UDP-xylose transporter[UDP-xylose Synthase] PMID: 19028698
  • 亚细胞定位：
    Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.
  • 蛋白家族：
    NAD(P)-dependent epimerase/dehydratase family, UDP-glucuronic acid decarboxylase subfamily
  • 数据库链接：

    HGNC: 17729

    OMIM: 609749

    KEGG: hsa:80146

    STRING: 9606.ENSP00000387019

    UniGene: Hs.469561

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