-
中文名称：
USP49兔多克隆抗体
-
货号：
CSB-PA025741GA01HU
-
规格：
-
其他：
产品详情
-
Uniprot No.：
-
基因名：
USP49
-
别名：
USP49 antibody; Ubiquitin carboxyl-terminal hydrolase 49 antibody; EC 3.4.19.12 antibody; Deubiquitinating enzyme 49 antibody; Ubiquitin thioesterase 49 antibody; Ubiquitin-specific-processing protease 49 antibody
-
宿主：
Rabbit
-
反应种属：
Human,Mouse,Rat
-
免疫原：
Human USP49
-
免疫原种属：
Homo sapiens (Human)
-
抗体亚型：
IgG
-
纯化方式：
Antigen Affinity purified
-
浓度：
It differs from different batches. Please contact us to confirm it.
-
保存缓冲液：
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
-
产品提供形式：
Liquid
-
应用范围：
ELISA,WB,IHC
-
Protocols：
-
储存条件：
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
-
货期：
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
-
用途：
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
靶点详情
-
功能：
Specifically deubiquitinates histone H2B at 'Lys-120' (H2BK120Ub). H2BK120Ub is a specific tag for epigenetic transcriptional activation and acts as a regulator of mRNA splicing. Deubiquitination is required for efficient cotranscriptional splicing of a large set of exons.
-
基因功能参考文献：
- Mechanistically, USP49 deubiquitinates and stabilizes FKBP51, which in turn enhances PHLPP's capability to dephosphorylate AKT. PMID: 28363942
- identifies USP49 as a histone H2B-specific deubiquitinase and uncovers a critical role for H2B deubiquitination in cotranscriptional pre-mRNA processing events. PMID: 23824326
-
亚细胞定位：
Nucleus.
-
蛋白家族：
Peptidase C19 family
-
数据库链接：
Most popular with customers
