USP28 Antibody

中文名称：

USP28兔多克隆抗体
货号：

CSB-PA271019
规格：

￥1100
图片：
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA271019(USP28 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: ×200)
其他：

产品详情

Uniprot No.：

Q96RU2
基因名：

USP28
宿主：

Rabbit
反应种属：

Human,Mouse,Rat
免疫原：

Synthetic peptide of Human USP28
免疫原种属：

Homo sapiens (Human)
标记方式：

Non-conjugated
抗体亚型：

IgG
纯化方式：

Antigen affinity purification
浓度：

It differs from different batches. Please contact us to confirm it.
保存缓冲液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
产品提供形式：

Liquid
应用范围：

ELISA,IHC
推荐稀释比：

Application Recommended Dilution

ELISA 1:2000-1:5000

IHC 1:25-1:100
Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
储存条件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
货期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Deubiquitinase involved in DNA damage response checkpoint and MYC proto-oncogene stability. Involved in DNA damage induced apoptosis by specifically deubiquitinating proteins of the DNA damage pathway such as CLSPN. Also involved in G2 DNA damage checkpoint, by deubiquitinating CLSPN, and preventing its degradation by the anaphase promoting complex/cyclosome (APC/C). In contrast, it does not deubiquitinate PLK1. Specifically deubiquitinates MYC in the nucleoplasm, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm and counteracting ubiquitination of MYC by the SCF(FBW7) complex. In contrast, it does not interact with isoform 4 of FBXW7 (FBW7gamma) in the nucleolus, allowing MYC degradation and explaining the selective MYC degradation in the nucleolus. Deubiquitinates ZNF304, hence preventing ZNF304 degradation by the proteasome and leading to the activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) in a subset of colorectal cancers (CRC) cells.
亚细胞定位：

Nucleus, nucleoplasm.
蛋白家族：

Peptidase C19 family, USP28 subfamily
数据库链接：

HGNC: 12625

OMIM: 610748

KEGG: hsa:57646

STRING: 9606.ENSP00000003302

UniGene: Hs.503891

Application	Recommended Dilution
ELISA	1:2000-1:5000
IHC	1:25-1:100