UBR3 Antibody, FITC conjugated

产品详情

产品名称：

Rabbit anti-Homo sapiens (Human) UBR3 Polyclonal antibody
Uniprot No.：

Q6ZT12
基因名：

UBR3
别名：

DKFZp434P117 antibody; DKFZp686N10185 antibody; E3 ubiquitin-protein ligase UBR3 antibody; FLJ37422 antibody; KIAA2024 antibody; MGC126489 antibody; N-recognin-3 antibody; Ubiquitin-protein ligase E3-alpha-3 antibody; Ubiquitin-protein ligase E3-alpha-III antibody; Ubr3 antibody; UBR3_HUMAN antibody; Zinc finger protein 650 antibody; ZNF 650 antibody; ZNF650 antibody
宿主：

Rabbit
反应种属：

Human
免疫原：

Recombinant Human E3 ubiquitin-protein ligase UBR3 protein (960-1113AA)
免疫原种属：

Homo sapiens (Human)
标记方式：

FITC
克隆类型：

Polyclonal
抗体亚型：

IgG
纯化方式：

>95%, Protein G purified
浓度：

It differs from different batches. Please contact us to confirm it.
保存缓冲液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
产品提供形式：

Liquid
储存条件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
货期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Does not bind to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. May play a role in Shh signaling by mediating the ubiquitination of Kif7. May be important for MYH9 function in certain tissues, possibly by regulating the ubiquitination of MYH9 and consequently affecting its interaction with MYO7A.
基因功能参考文献：
1. The human E3 ubiquitin ligase UBR3 has a major activity that polyubiquitylates APE1 at multiple lysine residues clustered on the N-terminal tail. PMID: 21933813
亚细胞定位：

Membrane; Multi-pass membrane protein.
蛋白家族：

UBR1 family
数据库链接：

HGNC: 30467

OMIM: 613831

KEGG: hsa:130507

STRING: 9606.ENSP00000396068

UniGene: Hs.379548