UBE2M Antibody, FITC conjugated
-
中文名称:UBE2M兔多克隆抗体, FITC偶联
-
货号:CSB-PA025468OC01HU
-
规格:¥880
-
其他:
产品详情
-
产品名称:Rabbit anti-Homo sapiens (Human) UBE2M Polyclonal antibody
-
Uniprot No.:
-
基因名:
-
别名:hUbc12 antibody; NEDD8 carrier protein antibody; NEDD8 conjugating enzyme Ubc12 antibody; NEDD8 protein ligase antibody; NEDD8-conjugating enzyme Ubc12 antibody; UBC-RS2 antibody; UBC12 antibody; UBC12_HUMAN antibody; ube2m antibody; ubiquitin carrier protein M antibody; Ubiquitin conjugating enzyme E2 M antibody; Ubiquitin-conjugating enzyme E2 M antibody; ubiquitin-protein ligase M antibody; yeast UBC12 homolog antibody
-
宿主:Rabbit
-
反应种属:Human
-
免疫原:Peptide sequence from Human NEDD8-conjugating enzyme Ubc12 protein (11-28AA)
-
免疫原种属:Homo sapiens (Human)
-
标记方式:FITC
-
克隆类型:Polyclonal
-
抗体亚型:IgG
-
纯化方式:Antigen Affinity Purified
-
浓度:It differs from different batches. Please contact us to confirm it.
-
保存缓冲液:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
产品提供形式:Liquid
-
储存条件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
-
货期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
-
用途:For Research Use Only. Not for use in diagnostic or therapeutic procedures.
相关产品
靶点详情
-
功能:Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. Involved in cell proliferation.
-
基因功能参考文献:
- the DCN1-UBC12 interaction is inhibited by DI-591, a high-affinity, cell-permeable small-molecule inhibitor that binds to purified recombinant human DCN1 and DCN2 proteins with K i values of 10-12 nM PMID: 29074978
- Furthermore, the authors characterized SENP8/DEN1 as the protease that counteracts Ubc12 auto-neddylation, and observed aberrant neddylation of Ubc12 and other NEDD8 conjugation pathway components in SENP8-deficient cells. PMID: 28475037
- GlyRS preferentially binds and protects Ubc12. PMID: 27348078
- Polymorphisms in the UBE2M gene are associated with cetuximab efficacy in colorectal cancer. PMID: 26206335
- UBE2M is required to maintain genome integrity by activating multiple Cullin ligases throughout the cell cycle. PMID: 25025768
- Distinct preferences of UBC12 and UBE2F peptides for inhibiting different DCNLs, including the oncogenic DCNL1. PMID: 23201271
- Our results demonstrate a role for UBE2M in mediating cytotoxicity of gemcitabine in human urothelial carcinoma cells. PMID: 21477582
显示更多
收起更多
-
蛋白家族:Ubiquitin-conjugating enzyme family, UBC12 subfamily
-
数据库链接:
Most popular with customers
-
-
YWHAB Recombinant Monoclonal Antibody
Applications: ELISA, WB, IHC, IF, FC
Species Reactivity: Human, Mouse, Rat
-
-
-
-
-
-