TSPEAR Antibody, Biotin conjugated

产品详情

产品名称：

Rabbit anti-Homo sapiens (Human) TSPEAR Polyclonal antibody
Uniprot No.：

Q8WU66
基因名：

TSPEAR
别名：

Thrombospondin-type laminin G domain and EAR repeat-containing protein antibody; TSEAR_HUMAN antibody; TSP-EAR antibody; TSPEAR antibody
宿主：

Rabbit
反应种属：

Human
免疫原：

Recombinant Human Thrombospondin-type laminin G domain and EAR repeat-containing protein (248-433AA)
免疫原种属：

Homo sapiens (Human)
标记方式：

Biotin
克隆类型：

Polyclonal
抗体亚型：

IgG
纯化方式：

>95%, Protein G purified
浓度：

It differs from different batches. Please contact us to confirm it.
保存缓冲液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
产品提供形式：

Liquid
应用范围：

ELISA
Protocols：

ELISA Protocol
储存条件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
货期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Plays a critical role in tooth and hair follicle morphogenesis through regulation of the Notch signaling pathway. May play a role in development or function of the auditory system.
基因功能参考文献：
1. TSPEAR mutation is associated with tooth agenesis. PMID: 30046887
2. using a luciferase-based reporter assay, we showed that TSPEAR knock-down is associated with decreased Notch signaling. In addition, NOTCH1 protein expression was reduced in patient scalp skin. Moreover, TSPEAR silencing in mouse hair follicle organ cultures was found to induce apoptosis in follicular epithelial cells, resulting in decreased hair bulb diameter PMID: 27736875
3. TSPEAR expression is significantly downregulated in human masticatory mucosa during wound healing PMID: 28005267
4. TSPEAR, cause disorders with auditory features: epilepsy, which can include auditory features in humans; audiogenic seizures in animals; and/or hearing impairments in humans and mice. PMID: 22678063
5. The TSPEAR/C21orf29 promoter is activated by Trichostatin A (TSA) treatment according to promoter reporter assays in HEK 293 cells. PMID: 20494980
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相关疾病：

Deafness, autosomal recessive, 98 (DFNB98)
亚细胞定位：

Secreted. Cell surface. Cell projection, stereocilium.
数据库链接：

HGNC: 1268

OMIM: 612920

KEGG: hsa:54084

STRING: 9606.ENSP00000321987

UniGene: Hs.660703