TRPC5 Antibody

1. Silencing of TRPC5 and inhibition of autophagy reverses adriamycin drug resistance in breast carcinoma via CaMKKbeta/AMPKalpha/mTOR pathway. PMID: 28600513
2. We demonstrated the essential role of glycolysis in TRPC5 induced chemoresistance in human CRC cells via maintaining [Ca(2+)] i homeostasis. PMID: 29463225
3. induces the epithelial-mesenchymal transition through the HIF-1alpha-Twist signaling pathway to promote tumor metastasis in colon cancer PMID: 28864720
4. TrpC5 causes a robust rise in [Ca2+]i, enhanced Wnt5a expression and nuclear translocation of beta-catenin, leading to reduced differentiation and enhanced cancer cell stemness. PMID: 27895148
5. that Arg-593, a residue located in the E4 loop near the TRPC5 extracellular Gd(3+) binding site, is critical for conferring the sensitivity to GPCR-Gq/11-PLC-dependent gating on TRPC5. PMID: 27920205
6. Transient receptor potential canonical 5 (TRPC5) protects against pain and vascular inflammation in arthritis and joint inflammation. PMID: 27165180
7. circulating exosome-carrying TRPC5 might act as a noninvasive chemoresistance marker and might serve as an adjuvant to the current imaging examination-based chemoresistance. PMID: 28032400
8. The essential role of TrpC5 in GLUT1 induction and chemoresistance in colorectal cancer. PMID: 28000878
9. TrpC5 plays an important role in VEGF-mediated tumor angiogenesis, suggesting its potential clinical value for anti-angiogenesis therapy PMID: 25579062
10. TRPC5 mRNA and protein levels were up-regulated in focal cortical dysplasia cortical lesions. PMID: 25085710
11. Suppressing TrpC5 expression decreased nuclear beta-catenin accumulation, reduced the induction of ABCB1, and reversed 5-fluorouracil neoplastic resistance. PMID: 25404731
12. these results suggest that hypoosmotic cell-swelling activates Gq-coupled receptors, which in turn enhance the activation of TRPC5 by regulating this channel membrane trafficking PMID: 24177920
13. Clemizole exhibits a sixfold selectivity for TRPC5. PMID: 25140002
14. Riluzole can activate TRPC5 heterologously expressed in HEK293 cells as well as those endogenously expressed in the U-87 glioblastoma cell line. PMID: 24117252
15. TrpC5-containing circulating extracellular vesicles may transfer chemoresistance. PMID: 24733904
16. Microvesicles from tumor cells transferred TrpC5 to endothelial cells, inducing the expression of P-glycoprotein by activation of the transcription factor NFATc3 (nuclear factor of activated T cells isoform c3). PMID: 24582564
17. Data using recombinant proteins expressed in vascular endothelial cells suggest that SigmaR1 (sigma 1-type opioid receptor) is not involved in regulation of calcium signaling via TRPC5/TRPM3 (transient receptor potential cation channels C5/M3). PMID: 23121507
18. Transient receptor potential channel TRPC5 is essential for P-glycoprotein induction in drug-resistant cancer cells. PMID: 22988121
19. Adipocyte TRPC1 and TRPC5 contribute a constitutively active heteromultimeric channel that negatively regulates adiponectin, and through which the omega-3 fatty acids enhance adiponectin's anti-inflammatory activities. PMID: 22668831
20. these results suggest that the Galpha(s)-cAMP pathway potentiates the activity of TRPC5 via facilitating intracellular Ca(2+) dynamics and increasing channel trafficking to the plasma membrane. PMID: 22490661
21. findings demonstrate that highly cold-sensitive TRPC5 channels are a molecular component for detection and regional adaptation to cold temperatures in the peripheral nervous system that is distinct from noxious cold sensing PMID: 22025699
22. TRPC5 and TRPC6 channels are known as the Ca(2+) influx pathways for a previously described, nonselective, cationic current in podocytes. PMID: 21980113
23. This study demonstrated a new mechanism of TRPC5 regulation via a cAMP signaling via Galpha(s) and protein kinase A. PMID: 21734191
24. TRPC5 channel sensitivities to antioxidants and hydroxylated stilbenes. PMID: 21127073
25. Nitric oxide donors fail to modulate activity of human TRPC5 channels exogenously expressed in HEK293 cells. PMID: 20390293
26. Stimulation of calcium-permeable TRPC5-containing channels may be an early event in cellular responses to oxidized phospholipids that couples to cell migration and requires an unidentified G protein-coupled receptor. PMID: 20378846
27. findings suggest intracellular Ca(2+)-calmodulin activates myosin light chain kinase thereby maintaining TRPC5 activity by promotion of membrane TRPC5 distribution under control of phosphorylation/dephosphorylation equilibrium of myoisin light chain PMID: 16284075
28. TRPC5 calcium channel has a lysophospholipid-sensing capability that confers the property of a lipid ionotropic receptor PMID: 16368680
29. TRPC-derived pool of calcium contributes to selective activation of calcineurin in diseased heart PMID: 16950785
30. TRPC5 is a broadly expressed calcium channel with capability to act as an integrator of extracellular and intracellular signals at the level of calcium entry--{REVIEW} PMID: 17217053
31. TRPC5 calcium channel has a role in bipolar phospholipid sensing [review] PMID: 17233612
32. TRPC5 is potentiated by protons and may act as a sensor of pH that links decreases in extracellular pH to Ca(2+) entry and depolarization PMID: 17884814
33. activity of TRPC5 channels may be linked to cellular metabolism via changes in ATP levels and could be involved in Ca(2+) overload occurring after ischemia when ATP is depleted PMID: 17925457
34. conclusion, TRPC5 is a molecular candidate for NSCC activated by muscarinic receptor stimulation. PMID: 17981154
35. analysis of a TRPC6-TRPC5 channel cascade that restricts endothelial cell movement PMID: 18495872
36. Results indicate complex functions for regulation of TRPC5 by PIP2, and suggest that membrane polyphosphoinositides may have at least two distinct functions in regulating TRPC5 channel activity. PMID: 18665391
37. TRPC5 forms Ca(2+)-activated cation channels that are functionally coupled to Ca(2+)-selective ion channels through local Ca(2+) increases beneath the plasma membrane PMID: 19815560

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HGNC: 12337

OMIM: 300334

KEGG: hsa:7224

STRING: 9606.ENSP00000262839

UniGene: Hs.657709