TPST1 Antibody, HRP conjugated

产品详情

产品名称：

Rabbit anti-Homo sapiens (Human) TPST1 Polyclonal antibody
Uniprot No.：

O60507
基因名：

TPST1
别名：

TPST1; Protein-tyrosine sulfotransferase 1; Tyrosylprotein sulfotransferase 1; TPST-1
宿主：

Rabbit
反应种属：

Human
免疫原：

Recombinant Human Protein-tyrosine sulfotransferase 1 protein (283-370AA)
免疫原种属：

Homo sapiens (Human)
标记方式：

HRP
克隆类型：

Polyclonal
抗体亚型：

IgG
纯化方式：

>95%, Protein G purified
浓度：

It differs from different batches. Please contact us to confirm it.
保存缓冲液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
产品提供形式：

Liquid
应用范围：

ELISA
Protocols：

ELISA Protocol
储存条件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
货期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.
基因功能参考文献：
1. TPST1 was significantly negatively correlated with the expression of cMet in lung cancer and may be a negative prognostic biomarker of lung cancer. PMID: 26238632
2. TPST1 rs3757417T>G polymorphisms are associated with colorectal cancer. PMID: 25079514
3. Affinity purified salivary TPST showed a single band of 50-54 kDa and is the first report characterizing a tyrosylprotein sulfotransferase in secretory fluid from the parotid gland PMID: 16244708
4. results exclude TPST1 as the causative gene for Shwachman-Diamond syndrome PMID: 12032733
5. Shear stress-dependent downregulation of TPST1 in human endothelium involves protein kinase C PMID: 12056800
6. Human tyrosylprotein sulfotransferase may be functional as homodimer/oligomer in the trans-Golgi compartment. PMID: 16859706
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亚细胞定位：

Golgi apparatus membrane; Single-pass type II membrane protein.
蛋白家族：

Protein sulfotransferase family
组织特异性：

Ubiquitous. Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
数据库链接：

HGNC: 12020

OMIM: 603125

KEGG: hsa:8460

STRING: 9606.ENSP00000302413

UniGene: Hs.421194