TNRC6C Antibody, FITC conjugated

产品详情

产品名称：

Rabbit anti-Homo sapiens (Human) TNRC6C Polyclonal antibody
Uniprot No.：

Q9HCJ0
基因名：

TNRC6C
别名：

KIAA1582 antibody; TNR6C_HUMAN antibody; TNRC 6C antibody; Tnrc6c antibody; Trinucleotide repeat containing 6C antibody; Trinucleotide repeat containing gene 6C protein antibody; Trinucleotide repeat-containing gene 6C protein antibody
宿主：

Rabbit
反应种属：

Human
免疫原：

Recombinant Human Trinucleotide repeat-containing gene 6C protein (157-421AA)
免疫原种属：

Homo sapiens (Human)
标记方式：

FITC
克隆类型：

Polyclonal
抗体亚型：

IgG
纯化方式：

>95%, Protein G purified
浓度：

It differs from different batches. Please contact us to confirm it.
保存缓冲液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
产品提供形式：

Liquid
储存条件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
货期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Plays a role in RNA-mediated gene silencing by micro-RNAs (miRNAs). Required for miRNA-dependent translational repression of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes.
基因功能参考文献：
1. These findings reveal that despite species-specific differences in the relative strength of the PABPC1-binding sites, the interaction between GW182 proteins and PABPC1 is critical for miRNA-mediated silencing in animal cells. PMID: 21063388
2. The authors show that a conserved motif in the human GW182 paralog TNRC6C interacts with the C-terminal domain of polyadenylate binding protein 1 (PABC) and present the crystal structure of the complex. PMID: 20098421
3. Through deletion and mutagenesis, study identified the C-terminal part of TNRC6C encompassing the RRM RNA-binding motif as a key effector domain mediating protein synthesis repression by TNRC6C. PMID: 19304925
4. Our findings indicate that TNRC6C, is recruited to miRNA targets through an interaction between their N-terminal domain and an Argonaute protein PMID: 19383768
蛋白家族：

GW182 family
数据库链接：

HGNC: 29318

OMIM: 610741

KEGG: hsa:57690

STRING: 9606.ENSP00000336783

UniGene: Hs.406810