TNP1 Antibody

中文名称：

TNP1兔多克隆抗体
货号：

CSB-PA024018LA01HU
规格：

￥440
图片：
Immunofluorescent analysis of Hela cells using CSB-PA024018LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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产品名称：

Rabbit anti-Homo sapiens (Human) TNP1 Polyclonal antibody
Uniprot No.：

P09430
基因名：

TNP1
别名：

Spermatid nuclear transition protein 1 antibody; Spermatid nuclear transition protein1 antibody; STP 1 antibody; STP-1 antibody; STP1 antibody; STP1_HUMAN antibody; TNP 1 antibody; TNP1 antibody; TP 1 antibody; TP-1 antibody; TP1 antibody; Transition protein 1 (during histone to protamine replacement) antibody; Transition protein1 antibody
宿主：

Rabbit
反应种属：

Human
免疫原：

Recombinant Human Spermatid nuclear transition protein 1 protein (12-50AA)
免疫原种属：

Homo sapiens (Human)

标记方式：

Non-conjugated

本页面中的产品，TNP1 Antibody (CSB-PA024018LA01HU)，的标记方式是Non-conjugated。对于TNP1 Antibody，我们还提供其他标记。见下表：

标记方式	货号	产品名称	应用
HRP	CSB-PA024018LB01HU	TNP1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA024018LC01HU	TNP1 Antibody, FITC conjugated
Biotin	CSB-PA024018LD01HU	TNP1 Antibody, Biotin conjugated	ELISA

克隆类型：

Polyclonal
抗体亚型：

IgG
纯化方式：

>95%, Protein G purified
浓度：

It differs from different batches. Please contact us to confirm it.
保存缓冲液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
产品提供形式：

Liquid
应用范围：

ELISA, IF
推荐稀释比：

Application Recommended Dilution

IF 1:50-1:200
Protocols：

ELISA Protocol
Immunofluorescence (IF) Protocol
储存条件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
货期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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功能：

Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction.
基因功能参考文献：
1. Among Systemic lupus erythematosus patients, 63.6% and 45.5% of those with lupus nephritis were positive for anti-RRP8 and anti-TNP1 antibodies, compared with 12.5% and 9.4% of Systemic lupus erythematosus patients without nephritis, respectively. PMID: 26098692
2. frequency of the haplotype GCG (H3) was increased in azoospermic men compared with fertile men. expression analysis of the TNP1 gene in obstructive azoospermic men showed that haplotypes of the TNP1 gene do not affect its expression level. PMID: 20522125
3. a deletion of 15 nucleotides encompassing the recognition site for the cAMP response element transcription factor was found in the 5'-promoter region of the TNP1 gene in infertile men; this deletion reduces TNP1 expression and may cause infertility PMID: 16291974
4. We found significantly lower levels of HILS1, TNP1, and TNP2 transcripts in spermatozoa from asthenozoospermic men compared to normozoospermic men. PMID: 17852044
5. The TNP1 contributes not only to successful fertilization, but may has an important impact in development of preimplantation embryos. PMID: 18292840
6. The presence of transition proteins (TP1 and/or TP2) in spermatids in semen indicates inhibition in the differentiation pathway from round spermatids to spermatozoa in infertile men. PMID: 18727729
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亚细胞定位：

Nucleus. Chromosome.
蛋白家族：

Nuclear transition protein 1 family
组织特异性：

Expressed by spermatids (at protein level).
数据库链接：

HGNC: 11951

OMIM: 190231

KEGG: hsa:7141

STRING: 9606.ENSP00000236979

UniGene: Hs.3017

TNP1 Antibody

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