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  4. TGIF2 Antibody, HRP conjugated

TGIF2 Antibody, HRP conjugated

说明书
  • 中文名称：
    TGIF2兔多克隆抗体, HRP偶联
  • 货号：
    CSB-PA884421LB01HU
  • 规格：
    ￥880
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) TGIF2 Polyclonal antibody
  • Uniprot No.：
    Q9GZN2
  • 基因名：
    TGIF2
  • 别名：
    5' TG 3' interacting factor 2 antibody; 5''-TG-3''-interacting factor 2 antibody; Homeobox protein TGIF2 antibody; TGF (beta) induced transcription factor 2 antibody; TGF beta induced factor 2 antibody; TGF-beta-induced transcription factor 2 antibody; TGFB induced factor 2 antibody; TGFB-induced factor 2 antibody; Tgif2 antibody; TGIF2_HUMAN antibody; Transforming growth factor beta induced factor 2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Homeobox protein TGIF2 protein (82-222AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    HRP
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
    ELISA Protocol
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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TGIF2 antibodies

TGIF2 Proteins

靶点详情

  • 功能：
    Transcriptional repressor, which probably repress transcription by binding directly the 5'-CTGTCAA-3' DNA sequence or by interacting with TGF-beta activated SMAD proteins. Probably represses transcription via the recruitment of histone deacetylase proteins.
  • 基因功能参考文献：
    1. Tgifs regulate ciliogenesis and suggests that Evi5l mediates at least part of this effect. PMID: 27956704
    2. Authors suggest that miR-148a inhibits OC cell proliferation and invasion partly through inhibition of TGFI2. Therefore, this study highlights the importance of the miR-148a/TGFI2 axis in the malignant progression of OC. PMID: 27712592
    3. Data show that TGFB-induced factor 2 protein (TGIF2) is involved in microRNA miR-541-3p-regulated cell proliferation, invasion, migration, as well as cell cycle of non-small lung cancer (NSCLC) cells. PMID: 27448300
    4. expression of miR-148a was regulated by DNA methylation and targeted by TGIF2. Its methylation may be a potential prognostic indicator in skin cancer PMID: 26638007
    5. miR-34a could inhibit tumor invasion and metastasis in gastric cancer by targeting Tgif2 PMID: 26464633
    6. Corneal fibroblasts demonstrate the expression of TGIF1 and TGIF2 transcription factors. These transcriptional repressors are critical, at least partially, in mediating the antifibrotic effect of vorinostat in the cornea. PMID: 26330748
    7. Shows that the homologous mouse Tgif2 gene is necessary for gastrulation. PMID: 20040491

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  • 亚细胞定位：
    Nucleus. Note=Excluded from nucleoli.
  • 蛋白家族：
    TALE/TGIF homeobox family
  • 组织特异性：
    Widely expressed. Highly expressed in heart, kidney and testis. Weakly expressed in brain and prostate.
  • 数据库链接：

    HGNC: 15764

    OMIM: 607294

    KEGG: hsa:60436

    STRING: 9606.ENSP00000362979

    UniGene: Hs.632264

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