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TFDP3 Antibody

说明书
  • 中文名称：
    TFDP3兔多克隆抗体
  • 货号：
    CSB-PA702134LA01HU
  • 规格：
    ￥440
  • 图片：
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA702134LA01HU at dilution of 1:100
    • Immunofluorescent analysis of HepG2 cells using CSB-PA702134LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) TFDP3 Polyclonal antibody
  • Uniprot No.：
    Q5H9I0
  • 基因名：
    TFDP3
  • 别名：
    Cancer/testis antigen 30 antibody; CT30 antibody; DP4 antibody; E2F like protein antibody; E2F-like antibody; HCA661 antibody; Hepatocellular carcinoma-associated antigen 661 antibody; TFDP3 antibody; TFDP3_HUMAN antibody; Transcription factor Dp family member 3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Transcription factor Dp family member 3 protein (61-196AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，TFDP3 Antibody (CSB-PA702134LA01HU)，的标记方式是Non-conjugated。对于TFDP3 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA702134LB01HU TFDP3 Antibody, HRP conjugated ELISA
    FITC CSB-PA702134LC01HU TFDP3 Antibody, FITC conjugated
    Biotin CSB-PA702134LD01HU TFDP3 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
    ELISA Protocol
    Immunohistochemistry (IHC) Protocol
    Immunofluorescence (IF) Protocol
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

产品评价

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TFDP3 antibodies

TFDP3 Proteins

靶点详情

  • 功能：
    Competitive inhibitor of E2F-mediated transactivation activity. Impairs E2F-mediated cell-cycle progression from G(1) to S phase.
  • 基因功能参考文献：
    1. Authors established a preclinical model of resistance to induction therapy to examine the functional relevance of TFDP3 to chemoresistance in MRD derived from Jurkat/E6-1. PMID: 27902457
    2. TFDP3 can bind to E2F1 molecule to form E2F/TFDP3 complex; and the localizations of TFDP3 and E2F1 molecules and the co-localization were different in different phases of cell cycle in the nucleus and cytoplasm, which indicated that the E2F/TFDP3 complex involved in the process of regulating the cell cycle. PMID: 28797103
    3. data highlight that TFDP3 is expressed in breast cancer, that it is a member of the cancer-testis antigen family and that it functions as a regulator in epithelial-mesenchymal transition PMID: 28114432
    4. TFDP3 was highly expressed in cancer tissues including prostate cancer tissues.TFDP3 was expressed in coordination with E2F1 in most prostate cancer tissues. PMID: 24406621
    5. Data gathered from cell lines, tumorigenicity studies, and primary hepatocellular carcinoma samples demonstrate a negative role of HIF-2alpha in tumors, which is mediated by the TFDP3/E2F1 pathway. PMID: 23212661
    6. Data show that TFDP3 upregulates the expression of autophagy gene LC3B and inhibits E2F1-induced apoptosis, and may play an important role in prostate cancer. PMID: 22482402
    7. DP-4 downregulating E2F-1 activity and contributes to a new pRb-independent mechanism for regulating cell cycle progression. PMID: 20559320
    8. TFDP3, a novel DP protein, inhibits DNA binding and transactivation by E2F PMID: 17062573

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  • 亚细胞定位：
    Nucleus. Cytoplasm. Note=Translocates to the nucleus on heterodimerization with E2F family members.
  • 蛋白家族：
    E2F/DP family
  • 组织特异性：
    Predominantly expressed in testis. Low level of expression in pancreas. Highly expressed in ovarian and colon cancer cell lines.
  • 数据库链接：

    HGNC: 24603

    OMIM: 300772

    KEGG: hsa:51270

    STRING: 9606.ENSP00000385461

    UniGene: Hs.142908

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