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  4. TCF20 Antibody, HRP conjugated

TCF20 Antibody, HRP conjugated

说明书
  • 中文名称：
    TCF20兔多克隆抗体, HRP偶联
  • 货号：
    CSB-PA887024LB01HU
  • 规格：
    ￥880
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) TCF20 Polyclonal antibody
  • Uniprot No.：
    Q9UGU0
  • 基因名：
    TCF20
  • 别名：
    TCF20 antibody; KIAA0292 antibody; SPBP antibody; Transcription factor 20 antibody; TCF-20 antibody; Nuclear factor SPBP antibody; Protein AR1 antibody; Stromelysin-1 PDGF-responsive element-binding protein antibody; SPRE-binding protein antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Transcription factor 20 protein (539-704AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    HRP
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
    ELISA Protocol
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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TCF20 antibodies

TCF20 Proteins

靶点详情

  • 功能：
    Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting a function as a coactivator.
  • 基因功能参考文献：
    1. Nonsense and one frameshift variant of TCF20 were identified the patients with intellectual disability and postnatal overgrowth. Such de novo variants of TCF20 may represent a novel differential diagnosis in the overgrowth syndrome spectrum. PMID: 27436265
    2. mutations in TCF20 are associated with Autism spectrum disorders PMID: 25228304
    3. SPBP is a transcriptional coactivator of NRF2 regulating expression of the autophagy receptor p62. PMID: 24416372
    4. evolutionary conservation of chromatin binding of SPBP and RAI1 PMID: 24205348
    5. Study has identified SPBP as a transcriptional coactivator of AR. We also show that Pax6 inhibits SPBP-mediated enhancement of AR activity on the AR target gene probasin promoter, a repression that was partly reversed by increased expression of SPBP. PMID: 21935435
    6. SPBP behaves as a repressor of activated ERalpha PMID: 15831449
    7. Interaction between SPBP and TopBP1 was found to be mediated by the ePHD domain of SPBP and the BRCT6 domain of TopBP1. PMID: 17913746

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Expressed in most tissues, except in ovary and prostate. Isoform 1 is exclusively expressed in brain, heart and testis, and this form predominates in liver and kidney. Isoform 2 predominates in lung.
  • 数据库链接：

    HGNC: 11631

    OMIM: 603107

    KEGG: hsa:6942

    STRING: 9606.ENSP00000352463

    UniGene: Hs.475018

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