SUSD4 Antibody, HRP conjugated

产品详情

产品名称：

Rabbit anti-Homo sapiens (Human) SUSD4 Polyclonal antibody
Uniprot No.：

Q5VX71
基因名：

SUSD4
别名：

SUSD4 antibody; UNQ196/PRO222 antibody; Sushi domain-containing protein 4 antibody
宿主：

Rabbit
反应种属：

Human
免疫原：

Recombinant Human Sushi domain-containing protein 4 protein (56-290AA)
免疫原种属：

Homo sapiens (Human)
标记方式：

HRP
克隆类型：

Polyclonal
抗体亚型：

IgG
纯化方式：

>95%, Protein G purified
浓度：

It differs from different batches. Please contact us to confirm it.
保存缓冲液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
产品提供形式：

Liquid
应用范围：

ELISA
Protocols：

ELISA Protocol
储存条件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
货期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Acts as complement inhibitor by disrupting the formation of the classical C3 convertase. Isoform 3 inhibits the classical complement pathway, while membrane-bound isoform 1 inhibits deposition of C3b via both the classical and alternative complement pathways.
基因功能参考文献：
1. SUSD4 expression in both breast cancer cells and T cells infiltrating the tumor-associated stroma is useful to predict better prognosis of breast cancer patients. PMID: 26480818
2. Membrane-bound isoform SUSD4a inhibits the classical and alternative complement pathways when expressed on the surface of Chinese hamster cells but not when expressed as a soluble, truncated protein. PMID: 23482636
3. analysis of cloning, expression, refolding, and tissue distribution of Sushi domain-containing protein 4 PMID: 20348246
亚细胞定位：

[Isoform 1]: Membrane; Single-pass type I membrane protein.; [Isoform 3]: Secreted.
组织特异性：

Isoform 3 is the predominant isoform in all tissues except cortex, cerebellum, kidney, and breast. Isoform 1 is found primarily in the esophagus and the brain.
数据库链接：

HGNC: 25470

OMIM: 615827

KEGG: hsa:55061

UniGene: Hs.497841