STYX Antibody, FITC conjugated

产品详情

产品名称：

Rabbit anti-Homo sapiens (Human) STYX Polyclonal antibody
Uniprot No.：

Q8WUJ0
基因名：

STYX
别名：

Protein tyrosine phosphatase like protein antibody; Protein tyrosine phosphatase-like protein antibody; Serine/threonine/tyrosine interacting protein antibody; Serine/threonine/tyrosine-interacting protein antibody; Styx antibody; STYX_HUMAN antibody
宿主：

Rabbit
反应种属：

Human
免疫原：

Recombinant Human Serine/threonine/tyrosine-interacting protein (1-223AA)
免疫原种属：

Homo sapiens (Human)
标记方式：

FITC
克隆类型：

Polyclonal
抗体亚型：

IgG
纯化方式：

Antigen Affinity Purified
浓度：

It differs from different batches. Please contact us to confirm it.
保存缓冲液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
产品提供形式：

Liquid
储存条件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
货期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Catalytically inactive phosphatase. Acts as a nuclear anchor for MAPK1/MAPK3 (ERK1/ERK2). Modulates cell-fate decisions and cell migration by spatiotemporal regulation of MAPK1/MAPK3 (ERK1/ERK2). By binding to the F-box of FBXW7, prevents the assembly of FBXW7 into the SCF E3 ubiquitin-protein ligase complex, and thereby inhibits degradation of its substrates. Plays a role in spermatogenesis.
基因功能参考文献：
1. The authors show that STYX binds to the F-box domain of FBXW7 and disables its recruitment into the SCF ubiquitin ligase complex. PMID: 28007894
2. Results suggest that STYX is a pseudophosphatase that uses the 'competitor' and 'anchor' mode of action to exert its biologic roles. [review] PMID: 28408485
3. results identify STYX as an important regulator of ERK1/2 signaling critical for cell migration PMID: 23847209
亚细胞定位：

Nucleus. Cytoplasm, cytosol.
蛋白家族：

Protein-tyrosine phosphatase family, Non-receptor class subfamily
数据库链接：

HGNC: 11447

OMIM: 615814

KEGG: hsa:6815

STRING: 9606.ENSP00000346599

UniGene: Hs.364980