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  4. ST6GALNAC6 Antibody, FITC conjugated

ST6GALNAC6 Antibody, FITC conjugated

说明书
  • 中文名称：
    ST6GALNAC6兔多克隆抗体, FITC偶联
  • 货号：
    CSB-PA850251LC01HU
  • 规格：
    ￥880
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ST6GALNAC6 Polyclonal antibody
  • Uniprot No.：
    Q969X2
  • 基因名：
    ST6GALNAC6
  • 别名：
    ST6GALNAC6 antibody; SIAT7F antibody; UNQ708/PRO1359 antibody; Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 antibody; EC 2.4.99.- antibody; GalNAc alpha-2,6-sialyltransferase VI antibody; ST6GalNAc VI antibody; ST6GalNAcVI antibody; hST6GalNAc VI antibody; Sialyltransferase 7F antibody; SIAT7-F antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 protein (65-333AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    FITC
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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ST6GALNAC6 antibodies

ST6GALNAC6 Proteins

靶点详情

  • 功能：
    Transfers the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc onto glycoproteins and glycolipids, forming an alpha-2,6-linkage. Produces branched type disialyl structures by transfer of a sialyl group onto the GalNAc or GlcNAc residue inside backbone core chains having a terminal sialic acid with an alpha-2,3-linkage on Gal. ST6GalNAcVI prefers glycolipids to glycoproteins, predominantly catalyzing the biosynthesis of ganglioside GD1alpha from GM1b. Besides GMb1, MSGG and other glycolipids, it shows activity towards sialyl Lc4Cer generating disialyl Lc4Cer, which can lead to the synthesis of disialyl Lewis a (Le(a)), suggested to be a cancer-associated antigen. Also has activity toward GD1a and GT1b, and can generate DSGG (disialylgalactosylgloboside) from MSGG (monosialylgalactosylgloboside).
  • 基因功能参考文献：
    1. novel substrate specificity of ST6GalNAc VI, which is responsible for the synthesis of disialyl Lea but not for alpha-series gangliosides in human colon tissues PMID: 12668675
    2. ST6GalNAc-VI and disialylgalactosylgloboside were found in proximal tubule epithelial cells in normal kidney tissues PMID: 17123352
  • 亚细胞定位：
    Golgi apparatus membrane; Single-pass type II membrane protein.
  • 蛋白家族：
    Glycosyltransferase 29 family
  • 组织特异性：
    Expressed in kidney, in proximal tubule epithelial cells. Expressed in colon cell lines.
  • 数据库链接：

    HGNC: 23364

    OMIM: 610135

    KEGG: hsa:30815

    STRING: 9606.ENSP00000291839

    UniGene: Hs.109672

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