SSU72 Antibody, FITC conjugated

产品详情

产品名称：

Rabbit anti-Homo sapiens (Human) SSU72 Polyclonal antibody
Uniprot No.：

Q9NP77
基因名：

SSU72
别名：

CTD phosphatase SSU72 antibody; HSPC182 antibody; Hypothetical protein FLJ10947 antibody; PNAS-120 antibody; RNA polymerase II subunit A C-terminal domain phosphatase SSU72 antibody; ssu72 antibody; Ssu72 RNA polymerase II CTD phosphatase homolog antibody; Ssu72 RNA polymerase II CTD phosphatase homolog (yeast) antibody; SSU72_HUMAN antibody
宿主：

Rabbit
反应种属：

Human
免疫原：

Recombinant Human RNA polymerase II subunit A C-terminal domain phosphatase SSU72 protein (1-194AA)
免疫原种属：

Homo sapiens (Human)
标记方式：

FITC
克隆类型：

Polyclonal
抗体亚型：

IgG
纯化方式：

>95%, Protein G purified
浓度：

It differs from different batches. Please contact us to confirm it.
保存缓冲液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
产品提供形式：

Liquid
储存条件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
货期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination. Plays a role in pre-mRNA polyadenylation via its interaction with SYMPK.
基因功能参考文献：
1. a hand-off model in which Ssu72 mediates a conformational transition in TFIIB, accounting for the role of Ssu72 in transcription reinitiation, gene looping, and promoter-terminator cross-talk. PMID: 29158257
2. Aurora B kinase directly targets Ssu72 phosphatase for regulation of sister chromatid cohesion during early mitosis. PMID: 24149858
3. The pSer7 phosphatase activity of Ssu72 is approximately 4000-fold lower than its pSer5 phosphatase activity toward a peptide substrate PMID: 23070812
4. Data suggest that Ssu72 is a novel cohesin-binding protein capable of regulating cohesion between sister chromatid arms. PMID: 20818333
5. crystal structure at 2.4 A resolution of the amino-terminal domain (residues 30-340) of human symplekin in a ternary complex with the Pol II carboxy-terminal domain (CTD) Ser 5 phosphatase Ssu72 and a CTD Ser 5 phosphopeptide PMID: 20861839
6. Molecular cloning and characterization of functions of human ssu72. PMID: 15659578
显示更多

收起更多
亚细胞定位：

Nucleus. Cytoplasm. Note=Predominantly in the cytosol.
蛋白家族：

SSU72 phosphatase family
数据库链接：

HGNC: 25016

OMIM: 617680

KEGG: hsa:29101

STRING: 9606.ENSP00000291386

UniGene: Hs.30026