SRRM4 Antibody, FITC conjugated

中文名称：

SRRM4兔多克隆抗体, FITC偶联
货号：

CSB-PA012292LC01HU
规格：

￥880
其他：

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产品名称：

Rabbit anti-Homo sapiens (Human) SRRM4 Polyclonal antibody
Uniprot No.：

A7MD48
基因名：

SRRM4
别名：

SRRM4 antibody; KIAA1853 antibody; Serine/arginine repetitive matrix protein 4 antibody; Medulloblastoma antigen MU-MB-2.76 antibody; Neural-specific serine/arginine repetitive splicing factor of 100 kDa antibody; Neural-specific SR-related protein of 100 kDa antibody; nSR100 antibody
宿主：

Rabbit
反应种属：

Human
免疫原：

Recombinant Human Serine/arginine repetitive matrix protein 4 protein (400-479AA)
免疫原种属：

Homo sapiens (Human)
标记方式：

FITC
克隆类型：

Polyclonal
抗体亚型：

IgG
纯化方式：

>95%, Protein G purified
浓度：

It differs from different batches. Please contact us to confirm it.
保存缓冲液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
产品提供形式：

Liquid
储存条件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
货期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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功能：

Splicing factor specifically required for neural cell differentiation. Acts in conjunction with nPTB/PTBP2 by binding directly to its regulated target transcripts and promotes neural-specific exon inclusion in many genes that function in neural cell differentiation. Required to promote the inclusion of neural-specific exon 10 in nPTB/PTBP2, leading to increased expression of neural-specific nPTB/PTBP2. Also promotes the inclusion of exon 16 in DAAM1 in neuron extracts. Promotes alternative splicing of REST transcripts to produce REST isoform 3 (REST4) with greatly reduced repressive activity, thereby activating expression of REST targets in neural cells. Plays an important role during embryonic development as well as in the proper functioning of the adult nervous system. Regulates alternative splicing events in genes with important neuronal functions.
基因功能参考文献：
1. data indicate that SRRM4 regulates alternative RNA splicing of the Bif-1 gene that enables PCa cells resistant to apoptotic stimuli under anti-cancer therapies, and may contribute to AdPC progression into t-NEPC. PMID: 29759485
2. SRRM4 regulates alternative splicing programs to drive neuroendocrine prostate cancer progression (an aggressive subtype of castration-resistant prostate cancer) under androgen receptor pathway inhibition. PMID: 27180064
3. Neuronal activity-dependent microexons are nSR100 targets and are misregulated in autism. PMID: 27984743
4. The splicing of REST by SRRM4 could promote the neuroendocrine phenotype in CRPC. PMID: 26071481
5. Neural microexons are regulated by the neuronal-specific splicing factor nSR100/SRRM4, through its binding to adjacent intronic enhancer motifs; neural microexons are frequently misregulated in the brains of individuals with autism spectrum disorder, and this misregulation is associated with reduced levels of nSR100. PMID: 25525873
6. findings show that nSR100 plays a role in the alternative splicing of REST in small cell lung cancer (SCLC); study provides new insight into the role of nSR100 in the expression of sREST, possibly in the pathogenesis of SCLC PMID: 23928058
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亚细胞定位：

Nucleus.
蛋白家族：

NSR100 family
组织特异性：

Specifically expressed in neuronal cells (at protein level). Expressed in the cerebellum.
数据库链接：

HGNC: 29389

OMIM: 613103

KEGG: hsa:84530

STRING: 9606.ENSP00000267260

UniGene: Hs.744964

SRRM4 Antibody, FITC conjugated

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